Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- SilodosinExisting use: Benign prostatic hyperplasia56.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Amiodarone HydrochlorideExisting use: Cardiac arrhythmia, Ventricular arrhythmia, Ventricular fibrillation and 1 more56.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
- AtogepantExisting use: Migraine disorder56.6% AI-predicted activityagainst M. tuberculosis36 registered studies
- PemigatinibExisting use: Cancer, Cholangiocarcinoma, Neoplasm56.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Gilteritinib FumarateExisting use: Acute myeloid leukemia, Myeloid leukemia, Neoplasm56.6% AI-predicted activityagainst M. tuberculosis3 registered studies
- PinacidilExisting use: Hypertension56.4% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Anagrelide HydrochlorideExisting use: Essential thrombocythemia, Myeloproliferative disorder, Neoplasm and 2 more56.4% AI-predicted activityagainst M. tuberculosis28 registered studies
- Bromodiphenhydramine HydrochlorideExisting use: Allergic disease56.4% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Conivaptan HydrochlorideExisting use: Cardiovascular disease, Heart failure56.4% AI-predicted activityagainst M. tuberculosis21 registered studies
- RisperidoneExisting use: Aggressive behavior, Autism, Bipolar disorder and 4 more56.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Lomitapide MesylateExisting use: Familial hypercholesterolemia, Homozygous familial hypercholesterolemia, Hypercholesterolemia56.4% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Quizartinib DihydrochlorideExisting use: Acute myeloid leukemia, Myeloid leukemia56.4% AI-predicted activityagainst M. tuberculosis4 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.