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AMR Drug RepurposingSmart Screeningresearch prototype

Levocetirizine Dihydrochloride

FDA-approved product (tablet, oral), marketed as Levocetirizine Dihydrochloride, Levocetirizine Hydrochloride, Xyzal and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Levocetirizine Dihydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic disease
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis
  • Skin disease
  • Urticaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Piperazine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Levocetirizine Dihydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Levocetirizine Dihydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Is Levocetirizine Less Sedating Than Cetirizine?

    NCT00826943 · start 2009-01

    Registered record
    Registry ID
    NCT00826943
    Conditions
    Allergic Rhinitis
    Interventions
    Cetirizine; Levocetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCetirizine; Levocetirizine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Phase 1 Study of Levocetirizine

    NCT02447393 · start 2008-03-18

    Registered record
    Registry ID
    NCT02447393
    Conditions
    Dermatitis
    Interventions
    levocetirizine; cetirizine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-03-18
    Completion
    2008-04-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis
    Interventionlevocetirizine; cetirizine; placebo
    PhasePhase 1
    Registry statusCompleted

  • A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

    NCT00621959 · start 2008-03

    Registered record
    Registry ID
    NCT00621959
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    levocetirizine dihydrochloride; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-06
    Enrolment
    596

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Interventionlevocetirizine dihydrochloride; placebo
    PhasePhase 4
    Registry statusCompleted

  • Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months

    NCT00628108 · start 2008-03

    Registered record
    Registry ID
    NCT00628108
    Conditions
    Allergic Rhinitis; Chronic Urticaria
    Interventions
    Levocetirizine 1.25 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-09
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis; Chronic Urticaria
    InterventionLevocetirizine 1.25 mg; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Levocetirizine DiHCl Tablets 5mg of Dr. Reddy's Under Fasting Conditions

    NCT01506076 · start 2007-12

    Registered record
    Registry ID
    NCT01506076
    Conditions
    Fasting
    Interventions
    Levocetirizine DiHCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-12
    Completion
    2008-01
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFasting
    InterventionLevocetirizine DiHCl
    PhasePhase 1
    Registry statusCompleted

  • Evaluation of Safety of Levocetirizine in Routine Clinical Practice-non- Interventional Study

    NCT00598780 · start 2007-09

    Registered record
    Registry ID
    NCT00598780
    Conditions
    Rhinitis Allergic, Persistent
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-09
    Completion
    2008-09
    Enrolment
    7,870

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis Allergic, Persistent
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Levocetirizine in the Treatment of Nasal Obstruction Due to Perennial Allergic Rhinitis

    NCT00439712 · start 2007-02

    Registered record
    Registry ID
    NCT00439712
    Conditions
    Perennial Allergic Rhinitis
    Interventions
    Levocetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-02
    Completion
    2007-05
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis
    InterventionLevocetirizine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing Seasonal Allergic Rhinitis (SAR) Symptoms in Ragweed Sensitive Subjects

    NCT00295022 · start 2006-07-29

    Registered record
    Registry ID
    NCT00295022
    Conditions
    Rhinitis, Allergic, Seasonal
    Interventions
    Placebo; Montelukast; Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07-29
    Completion
    2006-10-01
    Enrolment
    418

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal
    InterventionPlacebo; Montelukast; Levocetirizine
    PhasePhase 4
    Registry statusCompleted

  • Compare the Efficacy of Levocetirizine to Montelukast in Reducing Symptoms of SAR in Sensitive Subjects Exposed to Ragweed Pollen

    NCT00315523 · start 2006-07

    Registered record
    Registry ID
    NCT00315523
    Conditions
    Rhinitis, Allergic, Seasonal
    Interventions
    Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-07
    Completion
    2006-10
    Enrolment
    403

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal
    InterventionLevocetirizine
    PhasePhase 3
    Registry statusCompleted

  • CUTE (Chronic Urticaria Treatment Evaluation)

    NCT00264303 · start 2005-12

    Registered record
    Registry ID
    NCT00264303
    Conditions
    Chronic Idiopathic Urticaria
    Interventions
    Levocetirizine; Desloratadine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-12
    Completion
    2007-01
    Enrolment
    886

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Urticaria
    InterventionLevocetirizine; Desloratadine
    PhasePhase 4
    Registry statusCompleted

  • Randomized Phase III Study to Evaluate the Efficacy and Safety of Xyzal® (Levocetirizine) vs Zyrtec® (Cetirizine) in Subjects With Dermatitis and Eczema

    NCT00375713 · start 2005-10

    Registered record
    Registry ID
    NCT00375713
    Conditions
    Dermatitis; Eczema
    Interventions
    Levocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine; Standard topical steroid (1% hydrocortisone) ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-10
    Completion
    2006-05
    Enrolment
    466

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis; Eczema
    InterventionLevocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Wheal and Flare Reaction During 24 Hours in Allergic Volunteers.

    NCT00521170 · start 2004-11

    Registered record
    Registry ID
    NCT00521170
    Conditions
    Allergy
    Interventions
    Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-11
    Completion
    2005-01
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    InterventionLevocetirizine
    PhasePhase 1
    Registry statusCompleted

  • Open Study to Evaluate the Safety of Levocetirizine in Young Children (2 - 6 Years) Suffering From Allergic Rhinitis

    NCT00152412 · start 2004-06

    Registered record
    Registry ID
    NCT00152412
    Conditions
    Allergic Rhinitis
    Interventions
    Levocetirizine oral solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-06
    Completion
    2004-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionLevocetirizine oral solution
    PhasePhase 2
    Registry statusCompleted

  • Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial (NCT00152464)

    NCT00160563 · start 2004-06

    Registered record
    Registry ID
    NCT00160563
    Conditions
    Asthma
    Interventions
    LEVOCETIRIZINE; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2004-06
    Completion
    2006-03
    Enrolment
    207

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionLEVOCETIRIZINE; Placebo
    PhasePhase 3
    Registry statusTerminated

  • The Effect of Desloratadine and Levocetirizine on Nasal Obstruction (Study P03609)

    NCT00789152 · start 2003-12-01

    Registered record
    Registry ID
    NCT00789152
    Conditions
    Allergic Rhinitis
    Interventions
    desloratadine; levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-12-01
    Completion
    2004-05-01
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    Interventiondesloratadine; levocetirizine
    PhasePhase 3
    Registry statusCompleted