Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Sodium Gluconate

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Sodium Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Sodium Gluconate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli23.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis18.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sodium Gluconate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sodium Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Thread-Embedding Acupuncture Using the Longitudinal Oblique Technique From BL40 Toward BL57 on KOOS Scores and Joint Range of Motion in Knee Osteoarthritis

    NCT07833462 · start 2026-09-23

    Registered record
    Registry ID
    NCT07833462
    Conditions
    Knee Osteoarthritis
    Interventions
    Thread Embedding Acupuncture; Sham Thread Embedding Acupuncture
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09-23
    Completion
    2026-11-25
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Osteoarthritis
    InterventionThread Embedding Acupuncture; Sham Thread Embedding Acupuncture
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Copper Supplementation in Cirrhosis

    NCT07471542 · start 2026-03-15

    Registered record
    Registry ID
    NCT07471542
    Conditions
    Cirrhosis; Chronic Liver Disease; Fibrosis; Infection
    Interventions
    Copper Gluconate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-03-15
    Completion
    2028-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis; Chronic Liver Disease; Fibrosis; Infection
    InterventionCopper Gluconate
    PhaseNot applicable
    Registry statusRecruiting

  • Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth

    NCT07393802 · start 2026-03

    Registered record
    Registry ID
    NCT07393802
    Conditions
    Mouthwash; Chlorhexidine; Biofilm Formation; Periodontal Health
    Interventions
    Resveratrol-Based Mouthwash; Chlorhexidine Gluconate 0.12 % Mouthwash; Placebo mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-03
    Completion
    2026-05
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMouthwash; Chlorhexidine; Biofilm Formation; Periodontal Health
    InterventionResveratrol-Based Mouthwash; Chlorhexidine Gluconate 0.12 % Mouthwash; Placebo mouthwash
    PhasePhase 3
    Registry statusNot yet recruiting

  • A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery

    NCT07356323 · start 2026-02-19

    Registered record
    Registry ID
    NCT07356323
    Conditions
    Arthroplasty Replacement, Knee; Arthroplasty Total Hip Replacement
    Interventions
    3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-02-19
    Completion
    2026-10
    Enrolment
    179

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthroplasty Replacement, Knee; Arthroplasty Total Hip Replacement
    Intervention3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
    PhaseNot applicable
    Registry statusRecruiting

  • Early Intravenous Magnesium Sulfate and Its Impact on Cerebral Vasospasm in Traumatic Subarachnoid Hemorrhage

    NCT07252505 · start 2025-11

    Registered record
    Registry ID
    NCT07252505
    Conditions
    Trauma and Emergency Care
    Interventions
    Magnesium Sulfate 10 MG/ML
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Not yet recruiting
    Start
    2025-11
    Completion
    2027-10
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrauma and Emergency Care
    InterventionMagnesium Sulfate 10 MG/ML
    PhaseEarly phase 1
    Registry statusNot yet recruiting

  • ESP vs. EXORA Blocks for Analgesia in Laparoscopic Cholecystectomy

    NCT06900413 · start 2025-10-01

    Registered record
    Registry ID
    NCT06900413
    Conditions
    Erector Spinae Plane Block; Laparoscopic Cholecystectomy; Plane Block
    Interventions
    Group ESP; Group EXORA
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-01
    Completion
    2026-04-15
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErector Spinae Plane Block; Laparoscopic Cholecystectomy; Plane Block
    InterventionGroup ESP; Group EXORA
    PhaseNot applicable
    Registry statusCompleted

  • A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI

    NCT06465901 · start 2024-09-01

    Registered record
    Registry ID
    NCT06465901
    Conditions
    Surgical Site Infection
    Interventions
    Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower; Intraoperative wound wash (e.g. Granudacyn); DACC surgical wound dressing (e.g. Leukomed Sorbact)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-09-01
    Completion
    2026-09-30
    Enrolment
    10,092

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionChlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower; Intraoperative wound wash (e.g. Granudacyn); DACC surgical wound dressing (e.g. Leukomed Sorbact)
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath

    NCT06219226 · start 2024-04-18

    Registered record
    Registry ID
    NCT06219226
    Conditions
    Halitosis
    Interventions
    Chlorine dioxide mouthwash; Chlorhexidine mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2024-04-18
    Completion
    2025-12-18
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHalitosis
    InterventionChlorine dioxide mouthwash; Chlorhexidine mouthwash
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction

    NCT06290219 · start 2024-03-20

    Registered record
    Registry ID
    NCT06290219
    Conditions
    Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis); Effect of Drug
    Interventions
    platelet-rich plasma combined with hyaluronic acid; Zinc Gluconate 10 MG Oral Tablet; 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2024-03-20
    Completion
    2024-12-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTraumatic Olfactory Nerve Injury With Anosmia (Diagnosis); Effect of Drug
    Interventionplatelet-rich plasma combined with hyaluronic acid; Zinc Gluconate 10 MG Oral Tablet; 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
    PhasePhase 3
    Registry statusUnknown

  • Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.

    NCT06237712 · start 2024-01-26

    Registered record
    Registry ID
    NCT06237712
    Conditions
    Metabolic Acidosis; CKD; Electrolyte and Fluid Balance Conditions
    Interventions
    Dietary supplement consisting of 40 mmol/daily of potassium chloride; Dietary supplement consisting of 40 mmol/daily of potassium gluconate; Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate; Dietary supplement consisting of 40 mmol/daily of sodium chloride; Dietary supplement consisting of 40 mmol/daily of sodium bicarbonate; Placebo caps
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2024-01-26
    Completion
    2026-07
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Acidosis; CKD; Electrolyte and Fluid Balance Conditions
    InterventionDietary supplement consisting of 40 mmol/daily of potassium chloride; Dietary supplement consisting of 40 mmol/daily of potassium gluconate; Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate; Dietary supplement consisting of 40 mmol/daily of sodium chloride +2 more
    PhaseNot applicable
    Registry statusActive not recruiting

  • SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty

    NCT05919888 · start 2023-06-26

    Registered record
    Registry ID
    NCT05919888
    Conditions
    Surgery; Surgical Site Infection; Cutibacterium Acnes; Prosthetic-joint Infection
    Interventions
    Povidone-Iodine; SURGX Wound Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-06-26
    Completion
    2023-11-14
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery; Surgical Site Infection; Cutibacterium Acnes; Prosthetic-joint Infection
    InterventionPovidone-Iodine; SURGX Wound Gel
    PhasePhase 4
    Registry statusCompleted

  • Lactoferrin With Ferrous Gluconate Versus Ferrous Gluconate in Treatment of Iron Deficiency Anemia During Pregnancy

    NCT06252103 · start 2023-05-30

    Registered record
    Registry ID
    NCT06252103
    Conditions
    Lactoferrin With Ferrous Gluconate More Superior Than Ferrous Gluconate Alone in Treatment of Iron Deficiency Anemia
    Interventions
    Ferrous Gluconate 300 MG; ferrous gluconate with lactoferrin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-05-30
    Completion
    2023-12-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLactoferrin With Ferrous Gluconate More Superior Than Ferrous Gluconate Alone in Treatment of Iron Deficiency Anemia
    InterventionFerrous Gluconate 300 MG; ferrous gluconate with lactoferrin
    PhasePhase 4
    Registry statusCompleted

  • Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren

    NCT07309679 · start 2023-03-07

    Registered record
    Registry ID
    NCT07309679
    Conditions
    Plaque Score; Gingival Health; Streptococcus Mutans
    Interventions
    Chlorhexidine Digluconate 0.2% Mouthwash; Pomegranate Peel Extract Mouthwash; Neem Extract Mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-07
    Completion
    2023-11-07
    Enrolment
    156

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlaque Score; Gingival Health; Streptococcus Mutans
    InterventionChlorhexidine Digluconate 0.2% Mouthwash; Pomegranate Peel Extract Mouthwash; Neem Extract Mouthwash
    PhaseNot applicable
    Registry statusCompleted

  • Zinc Deficiency Treatment in Celiac Disease: Supplementation Versus Diet

    NCT05782257 · start 2022-12-08

    Registered record
    Registry ID
    NCT05782257
    Conditions
    Celiac Disease; Nutrient Deficiency
    Interventions
    Zinc Supplementation; Zn-Optimized Diet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-12-08
    Completion
    2024-09-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCeliac Disease; Nutrient Deficiency
    InterventionZinc Supplementation; Zn-Optimized Diet
    PhaseNot applicable
    Registry statusUnknown

  • Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy.

    NCT05464498 · start 2022-06-13

    Registered record
    Registry ID
    NCT05464498
    Conditions
    Tendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    Interventions
    MD-Tissue Collagen Medical Device; eccentric strengthening protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-06-13
    Completion
    2026-11-01
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    InterventionMD-Tissue Collagen Medical Device; eccentric strengthening protocol
    PhaseNot applicable
    Registry statusRecruiting