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AMR Drug RepurposingSmart Screeningresearch prototype

Tetracycline Hydrochloride

FDA-approved product (suspension, oral), marketed as Achromycin, Achromycin V, Actisite and 12 more.

Registered studies
50+
Lab records
46
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tetracycline Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Duodenal ulcer
  • Eye infection
  • Fever
  • Infection
  • Ornithosis
  • Skin infection
  • Tularemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracycline and derivatives; Tetracyclines; Antibiotics; Antiinfectives
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA07; WHO ATC D06AA04; WHO ATC S01AA09

Repurposing investigation

Tetracycline Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli87.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae90.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis68.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 1 of 1 lab record
  • K. pneumoniae: measured active in 25 of 43 lab records
Open Tetracycline Hydrochloride in ChEMBL Registered studies below
Show the 46 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tetracycline Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety of 14-Day Vonoprazan-Minocycline Dual Therapy for Helicobacter Pylori Eradication

    NCT07757919 · start 2026-09-01

    Registered record
    Registry ID
    NCT07757919
    Conditions
    HELICOBACTER PYLORI INFECTIONS
    Interventions
    Vonoprazan-Amoxicillin Dual Therapy; Vonoprazan-Tetracycline Dual Therapy; Vonoprazan-Minocycline Dual Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-09-01
    Completion
    2027-12-30
    Enrolment
    492

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHELICOBACTER PYLORI INFECTIONS
    InterventionVonoprazan-Amoxicillin Dual Therapy; Vonoprazan-Tetracycline Dual Therapy; Vonoprazan-Minocycline Dual Therapy
    PhasePhase 4
    Registry statusNot yet recruiting

  • Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression

    NCT07750938 · start 2026-08-01

    Registered record
    Registry ID
    NCT07750938
    Conditions
    HELICOBACTER PYLORI INFECTIONS
    Interventions
    Keverprazan Hydrochloride 20 mg TID; Minocycline 100 mg (10-Day Regimen); Keverprazan Hydrochloride 20 mg BID; Bismuth Potassium Citrate 240 mg; Amoxicillin 1000 mg; Minocycline 100 mg (14-Day Regimen)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-08-01
    Completion
    2028-08-10
    Enrolment
    316

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHELICOBACTER PYLORI INFECTIONS
    InterventionKeverprazan Hydrochloride 20 mg TID; Minocycline 100 mg (10-Day Regimen); Keverprazan Hydrochloride 20 mg BID; Bismuth Potassium Citrate 240 mg +2 more
    PhasePhase 4
    Registry statusNot yet recruiting

  • Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis

    NCT07526987 · start 2026-06-05

    Registered record
    Registry ID
    NCT07526987
    Conditions
    Ischaemic Stroke
    Interventions
    Minocycline Hydrochloride Capsule (50 mg per capsule); Placebo of Minocycline Hydrochloride Capsule (50 mg per capsule, containing 0 mg of minocycline)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2026-06-05
    Completion
    2028-12-31
    Enrolment
    934

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschaemic Stroke
    InterventionMinocycline Hydrochloride Capsule (50 mg per capsule); Placebo of Minocycline Hydrochloride Capsule (50 mg per capsule, containing 0 mg of minocycline)
    PhasePhase 3
    Registry statusRecruiting

  • Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)

    NCT07594314 · start 2026-05-21

    Registered record
    Registry ID
    NCT07594314
    Conditions
    Acute Ischemic Stroke; Vessel Occlusion; Endovascular Thrombectomy; Anterior Circulation Brain Infarction; Minocycline
    Interventions
    Minocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Recruiting
    Start
    2026-05-21
    Completion
    2028-12
    Enrolment
    860

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Ischemic Stroke; Vessel Occlusion; Endovascular Thrombectomy; Anterior Circulation Brain Infarction +1 more
    InterventionMinocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    PhasePhase 2 / Phase 3
    Registry statusRecruiting

  • Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)

    NCT07594301 · start 2026-05-19

    Registered record
    Registry ID
    NCT07594301
    Conditions
    Acute Ischemic Stroke; Endovascular Thrombectomy; Minocycline; Posterior Circulation; Arterial Occlusion
    Interventions
    Minocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Recruiting
    Start
    2026-05-19
    Completion
    2028-12
    Enrolment
    234

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Ischemic Stroke; Endovascular Thrombectomy; Minocycline; Posterior Circulation +1 more
    InterventionMinocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    PhasePhase 2 / Phase 3
    Registry statusRecruiting

  • Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage

    NCT07338175 · start 2026-04-02

    Registered record
    Registry ID
    NCT07338175
    Conditions
    Intracerebral Hemorrhage
    Interventions
    Minocycline hydrochloride capsules; Placebo capsules of Minocycline hydrochloride capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2026-04-02
    Completion
    2028-12
    Enrolment
    1,192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage
    InterventionMinocycline hydrochloride capsules; Placebo capsules of Minocycline hydrochloride capsules
    PhasePhase 3
    Registry statusRecruiting

  • Minocycline in Stroke Study at Maimonides

    NCT07237048 · start 2026-02-02

    Registered record
    Registry ID
    NCT07237048
    Conditions
    Stroke; Ischemia Stroke; Hemorrhagic Strokes; Mortality; Morbidity; Cerebrovascular Accident (Stroke); Intracerebral Haemorrhage (ICH)
    Interventions
    Minocycline 200mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Recruiting
    Start
    2026-02-02
    Completion
    2028-12
    Enrolment
    1,164

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke; Ischemia Stroke; Hemorrhagic Strokes; Mortality +3 more
    InterventionMinocycline 200mg
    PhasePhase 2 / Phase 3
    Registry statusRecruiting

  • Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke

    NCT05367362 · start 2025-12-01

    Registered record
    Registry ID
    NCT05367362
    Conditions
    Acute Ischemic Stroke
    Interventions
    Minocyclin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2025-12-01
    Completion
    2026-03-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Ischemic Stroke
    InterventionMinocyclin
    PhasePhase 2
    Registry statusWithdrawn

  • Antihypertensive Mechanisms of Minocycline in Resistant Hypertension

    NCT06246396 · start 2025-01-08

    Registered record
    Registry ID
    NCT06246396
    Conditions
    Hypertension, Resistant to Conventional Therapy
    Interventions
    Minocycline Hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-01-08
    Completion
    2028-07
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension, Resistant to Conventional Therapy
    InterventionMinocycline Hydrochloride; Placebo
    PhasePhase 4
    Registry statusRecruiting

  • Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel

    NCT06255067 · start 2024-02-25

    Registered record
    Registry ID
    NCT06255067
    Conditions
    Periodontitis
    Interventions
    Minocycline hydrochloride with noisome carrier; Minocycline Hydrochloride only
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2024-02-25
    Completion
    2024-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis
    InterventionMinocycline hydrochloride with noisome carrier; Minocycline Hydrochloride only
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Non-surgical Treatment of Peri-implantitis Using Chitosan Brush and Tetracycline Slurry

    NCT06695559 · start 2024-02-05

    Registered record
    Registry ID
    NCT06695559
    Conditions
    Periimplantitis; Periimplant Diseases
    Interventions
    Labrida Bioclean; Tetracycline slurry
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2024-02-05
    Completion
    2025-05-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriimplantitis; Periimplant Diseases
    InterventionLabrida Bioclean; Tetracycline slurry
    PhasePhase 4
    Registry statusCompleted

  • Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

    NCT06603688 · start 2023-11-20

    Registered record
    Registry ID
    NCT06603688
    Conditions
    Helicobacter Pylori Infection; Chronic Gastritis
    Interventions
    esomeprazole; Bismuth; Amoxicillin; clarithromycin; Berberine; Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-11-20
    Completion
    2024-12-01
    Enrolment
    548

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection; Chronic Gastritis
    Interventionesomeprazole; Bismuth; Amoxicillin; clarithromycin +2 more
    PhasePhase 4
    Registry statusUnknown

  • Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis

    NCT06033846 · start 2023-10-01

    Registered record
    Registry ID
    NCT06033846
    Conditions
    Autoimmune Encephalitis
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2023-10-01
    Completion
    2025-07-16
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutoimmune Encephalitis
    InterventionMinocycline
    PhasePhase 2
    Registry statusCompleted

  • Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke

    NCT05836740 · start 2023-05-19

    Registered record
    Registry ID
    NCT05836740
    Conditions
    Ischemic Stroke, Acute
    Interventions
    Minocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2023-05-19
    Completion
    2024-08-15
    Enrolment
    1,724

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Stroke, Acute
    InterventionMinocycline hydrochloride capsule; Placebo capsules of Minocycline hydrochloride capsules
    PhasePhase 3
    Registry statusCompleted

  • Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)

    NCT05512910 · start 2023-03-04

    Registered record
    Registry ID
    NCT05512910
    Conditions
    Ischemic Stroke, Acute; Minocycline; Endovascular Treatment; Basilar Artery Occlusion
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2023-03-04
    Completion
    2025-06-04
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Stroke, Acute; Minocycline; Endovascular Treatment; Basilar Artery Occlusion
    InterventionMinocycline
    PhasePhase 4
    Registry statusActive not recruiting