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AMR Drug RepurposingSmart Screeningresearch prototype

Pergolide Mesylate

FDA-approved product (tablet, oral), marketed as Pergolide Mesylate, Permax.

Registered studies
12
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Pergolide Mesylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Parkinson disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Dopamine agonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA40.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae34.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis52.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

12registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Pergolide Mesylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pergolide Mesylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • MOTION, Safinamide in Early IPD, as add-on to Dopamine Agonist

    NCT00605683 · start 2007-11

    Registered record
    Registry ID
    NCT00605683
    Conditions
    Idiopathic Parkinson's Disease
    Interventions
    Safinamide (as add-on therapy); Safinamide (as add-on therapy); Safinamide (as add-on therapy)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2012-03
    Enrolment
    679

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIdiopathic Parkinson's Disease
    InterventionSafinamide (as add-on therapy); Safinamide (as add-on therapy); Safinamide (as add-on therapy)
    PhasePhase 3
    Registry statusCompleted

  • Observational Study of Pergolide Mesylate and Cardiac Valvulopathy

    NCT00311532 · start 2006-03

    Registered record
    Registry ID
    NCT00311532
    Conditions
    Parkinson Disease
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-03
    Completion
    2007-05
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson Disease
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Observational Study of Heart Valve Disease in Patients With Parkinson's Disease Treated With Pergolide

    NCT00202657 · start 2005-04

    Registered record
    Registry ID
    NCT00202657
    Conditions
    Parkinson's Disease; Pergolide
    Interventions
    echocardiography
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-04
    Completion
    2007-02
    Enrolment
    149

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson's Disease; Pergolide
    Interventionechocardiography
    PhaseNot recorded
    Registry statusCompleted

  • Pergolide Treatment and Valvular Heart Disease

    NCT00234364 · start 2005-03

    Registered record
    Registry ID
    NCT00234364
    Conditions
    Heart Valve Diseases; Parkinson's Disease; Pergolide; Fibrosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-03
    Completion
    2007-09
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Valve Diseases; Parkinson's Disease; Pergolide; Fibrosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia

    NCT01066403 · start 2003-10

    Registered record
    Registry ID
    NCT01066403
    Conditions
    Schizophrenia
    Interventions
    Pergolide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-10
    Completion
    2008-03
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionPergolide
    PhaseNot applicable
    Registry statusCompleted

  • Effective Adjunctive Use of Pergolide for Cognitive Impairment and Negative Symptoms in Schizophrenia

    NCT00197483 · start 2003-03

    Registered record
    Registry ID
    NCT00197483
    Conditions
    Schizophrenia; Negative Symptoms; Cognitive Impairments
    Interventions
    Pergolide (drug)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Suspended
    Start
    2003-03
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Negative Symptoms; Cognitive Impairments
    InterventionPergolide (drug)
    PhaseNot recorded
    Registry statusSuspended

  • Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder

    NCT00252044 · start 2000-10

    Registered record
    Registry ID
    NCT00252044
    Conditions
    Schizotypal Personality Disorder; Other Personality Disorders
    Interventions
    Pergolide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2000-10
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizotypal Personality Disorder; Other Personality Disorders
    InterventionPergolide
    PhaseNot applicable
    Registry statusUnknown

  • Dose Response Trial of Pergolide for Cocaine Dependence - 1

    NCT00000248 · start 1996-02

    Registered record
    Registry ID
    NCT00000248
    Conditions
    Cocaine-Related Disorders
    Interventions
    Pergolide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1996-02
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders
    InterventionPergolide
    PhasePhase 3
    Registry statusCompleted

  • Pergolide Treatment for Substance Abusers - 4

    NCT00000269 · start 1995-10

    Registered record
    Registry ID
    NCT00000269
    Conditions
    Cocaine-Related Disorders; Substance-Related Disorders
    Interventions
    Pergolide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1995-10
    Completion
    2001-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders; Substance-Related Disorders
    InterventionPergolide
    PhasePhase 2
    Registry statusCompleted

  • Randomized Study of Pergolide in Children With Tourette Syndrome

    NCT00004433 · start 1994-12

    Registered record
    Registry ID
    NCT00004433
    Conditions
    Tourette Syndrome
    Interventions
    pergolide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1994-12
    Completion
    2002-09
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTourette Syndrome
    Interventionpergolide
    PhaseNot applicable
    Registry statusCompleted

  • IV Cocaine Abuse: A Laboratory Model - 4

    NCT00000215

    Registered record
    Registry ID
    NCT00000215
    Conditions
    Cocaine-Related Disorders
    Interventions
    Pergolide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders
    InterventionPergolide
    PhasePhase 2
    Registry statusCompleted

  • Compassionate Use Study of Pergolide in Patients With Parkinson's Disease

    NCT00624741

    Registered record
    Registry ID
    NCT00624741
    Conditions
    Parkinson Disease
    Interventions
    Pergolide
    Study type
    EXPANDED_ACCESS
    Phase
    Not recorded
    Registry status
    No longer available
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson Disease
    InterventionPergolide
    PhaseNot recorded
    Registry statusNo longer available