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AMR Drug RepurposingSmart Screeningresearch prototype

Tuberculosis

Supported pathogenM. tuberculosisMycobacterium tuberculosis

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “tuberculosis”, “mycobacterium tuberculosis”, “tb”, “latent tb”.

Show all 80

Laboratory measurements against M. tuberculosis recorded in ChEMBL.

Show all 54

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against M. tuberculosis that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

M. tuberculosis has 870 repurposing candidates in all. 35 are already listed above, with a registered study for this condition or a laboratory record, so the other 835 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for M. tuberculosis, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started244 of 249 have a start date · most in 2023 (19)
199420102026

  • Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial

    NCT01442428 · start 2014-01

    Registered record
    Registry ID
    NCT01442428
    Conditions
    Immune Reconstitution Inflammatory Syndrome; Immune Reconstitution Syndrome; Tuberculosis; HIV-infection/Aids
    Interventions
    Dexamethasone; Atorvastatin; Naproxen; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2014-01
    Completion
    2016-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmune Reconstitution Inflammatory Syndrome; Immune Reconstitution Syndrome; Tuberculosis; HIV-infection/Aids
    InterventionDexamethasone; Atorvastatin; Naproxen; Placebo
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • Pharmacokinetic Parameters of Co-trimoxazole

    NCT01832987 · start 2013-10

    Registered record
    Registry ID
    NCT01832987
    Conditions
    Tuberculosis
    Interventions
    co-trimoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-10
    Completion
    2014-08
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    Interventionco-trimoxazole
    PhasePhase 2
    Registry statusCompleted

  • Effectiveness of a Simplified Short Regimen for Multidrug Resistant Tuberculosis in Uzbekistan

    NCT02496572 · start 2013-09

    Registered record
    Registry ID
    NCT02496572
    Conditions
    Multidrug Resistant Tuberculosis
    Interventions
    Short course MDR-TB treatment regimen
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2013-09
    Completion
    2016-04
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultidrug Resistant Tuberculosis
    InterventionShort course MDR-TB treatment regimen
    PhaseNot recorded
    Registry statusUnknown

  • Performance of IGRAs for TB Infection Diagnosis in Elderly

    NCT01895582 · start 2013-07-17

    Registered record
    Registry ID
    NCT01895582
    Conditions
    Ageing; Tuberculosis
    Interventions
    Blood samples
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2013-07-17
    Completion
    2019-03-17
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAgeing; Tuberculosis
    InterventionBlood samples
    PhaseNot recorded
    Registry statusTerminated

  • Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV

    NCT01601626 · start 2013-07-13

    Registered record
    Registry ID
    NCT01601626
    Conditions
    HIV Infection; Tuberculosis
    Interventions
    Standard-dose Lopinavir/Ritonavir; Double-dose Lopinavir/Ritonavir; Raltegravir; Isoniazid; Pyridoxine; Pyrazinamide; Ethambutol; Rifabutin; Rifampin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-07-13
    Completion
    2017-06-28
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection; Tuberculosis
    InterventionStandard-dose Lopinavir/Ritonavir; Double-dose Lopinavir/Ritonavir; Raltegravir; Isoniazid +5 more
    PhasePhase 2
    Registry statusTerminated

  • Research on New Regimens for Retreatment Pulmonary Tuberculosis

    NCT02331823 · start 2013-06

    Registered record
    Registry ID
    NCT02331823
    Conditions
    Reinfection Pulmonary Tuberculosis
    Interventions
    Isoniazid Aminosalicylate Tablets; Streptomycin injectable
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-06
    Completion
    2016-12
    Enrolment
    864

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionReinfection Pulmonary Tuberculosis
    InterventionIsoniazid Aminosalicylate Tablets; Streptomycin injectable
    PhasePhase 4
    Registry statusUnknown

  • Evaluation of the Pharmacokinetics of Antituberculosis Drugs and Tuberculosis Treatment Outcomes

    NCT01782950 · start 2013-02

    Registered record
    Registry ID
    NCT01782950
    Conditions
    AIDS With Tuberculosis
    Interventions
    Rifampicin, Isoniazid, Ethambutol, Pyrazinamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-02
    Completion
    2016-03
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAIDS With Tuberculosis
    InterventionRifampicin, Isoniazid, Ethambutol, Pyrazinamide
    PhasePhase 4
    Registry statusUnknown

  • Interaction Study to Assess the Pharmacokinetic Interaction of Oral Administration of Rifapentine on ATRIPLA™ in HIV Patients

    NCT01690403 · start 2012-12

    Registered record
    Registry ID
    NCT01690403
    Conditions
    Tuberculosis
    Interventions
    rifapentine (M000473); EFZ EMT TDF
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-12
    Completion
    2014-03
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    Interventionrifapentine (M000473); EFZ EMT TDF
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics of Levofloxacin and Capreomycin in Multidrug-Resistant Tuberculosis Patients

    NCT02169141 · start 2012-11

    Registered record
    Registry ID
    NCT02169141
    Conditions
    Tuberculosis
    Interventions
    Pharmacokinetics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPharmacokinetics
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z)

    NCT01691534 · start 2012-10

    Registered record
    Registry ID
    NCT01691534
    Conditions
    Pulmonary Tuberculosis
    Interventions
    TMC207 (J); PA-824 (PA); pyrazinamide (Z); clofazimine (C); Rifafour
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-05
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionTMC207 (J); PA-824 (PA); pyrazinamide (Z); clofazimine (C) +1 more
    PhasePhase 2
    Registry statusCompleted

  • Effect of PA-824 and of PA-824 Plus Moxifloxacin on the QTc Interval in Healthy Volunteers

    NCT01674218 · start 2012-09

    Registered record
    Registry ID
    NCT01674218
    Conditions
    Tuberculosis
    Interventions
    Moxifloxacin; PA-824; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-09
    Completion
    2012-12
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionMoxifloxacin; PA-824; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Evaluation of Diabetes Control and Effect on Transmission and Development of Tuberculosis

    NCT03498534 · start 2012-09

    Registered record
    Registry ID
    NCT03498534
    Conditions
    Latent Tuberculosis; Diabetes Mellitus
    Interventions
    Isoniazid 300Mg Tab; Isoniazid 300 MG; Isoniazid 300 MG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2012-09
    Completion
    2013-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLatent Tuberculosis; Diabetes Mellitus
    InterventionIsoniazid 300Mg Tab; Isoniazid 300 MG; Isoniazid 300 MG
    PhasePhase 4
    Registry statusWithdrawn

  • Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults

    NCT01574638 · start 2012-06

    Registered record
    Registry ID
    NCT01574638
    Conditions
    Tuberculosis
    Interventions
    Rifapentine (RPT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-06
    Completion
    2013-06
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifapentine (RPT)
    PhasePhase 1
    Registry statusCompleted

  • Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)

    NCT01404312 · start 2012-05-23

    Registered record
    Registry ID
    NCT01404312
    Conditions
    Tuberculosis; HIV Infections
    Interventions
    Rifapentine (RPT); Isoniazid (INH); Pyridoxine (Vitamin B6)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-05-23
    Completion
    2017-11-14
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; HIV Infections
    InterventionRifapentine (RPT); Isoniazid (INH); Pyridoxine (Vitamin B6)
    PhasePhase 3
    Registry statusCompleted

  • Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

    NCT01571414 · start 2012-05

    Registered record
    Registry ID
    NCT01571414
    Conditions
    Tuberculosis
    Interventions
    PA-824; Efavirenz (EFV); Lopinavir/Ritonavir (LPV/r); Rifampin (RIF)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-05
    Completion
    2013-05
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPA-824; Efavirenz (EFV); Lopinavir/Ritonavir (LPV/r); Rifampin (RIF)
    PhasePhase 1
    Registry statusCompleted