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AMR Drug RepurposingSmart Screeningresearch prototype

Tuberculosis

Supported pathogenM. tuberculosisMycobacterium tuberculosis

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “tuberculosis”, “mycobacterium tuberculosis”, “tb”, “latent tb”.

Show all 80

Laboratory measurements against M. tuberculosis recorded in ChEMBL.

Show all 54

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against M. tuberculosis that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

M. tuberculosis has 870 repurposing candidates in all. 35 are already listed above, with a registered study for this condition or a laboratory record, so the other 835 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for M. tuberculosis, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started244 of 249 have a start date · most in 2023 (19)
199420102026

  • Evaluation of Xpert MTB/RIF Assay for the Rapid Identification of TB and TB Rifampin Resistance in Pulmonary Tuberculosis Suspects

    NCT01587469 · start 2012-05

    Registered record
    Registry ID
    NCT01587469
    Conditions
    Tuberculosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-05
    Completion
    2014-02-21
    Enrolment
    992

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)

    NCT01498419 · start 2012-03

    Registered record
    Registry ID
    NCT01498419
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Moxifloxacin (M); Pretomid (Pa); Pyrazinamide (Z); Rifafour
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-03
    Completion
    2013-07
    Enrolment
    207

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionMoxifloxacin (M); Pretomid (Pa); Pyrazinamide (Z); Rifafour
    PhasePhase 2
    Registry statusCompleted

  • "Efficacy and Safety of Levofloxacin vs Isoniazid in Latent Tuberculosis Infection in Liver Transplant Patients".

    NCT01761201 · start 2012-01

    Registered record
    Registry ID
    NCT01761201
    Conditions
    Latent Tuberculosis Infection; Infection in Solid Organ Transplant Recipients
    Interventions
    Levofloxacin; Isoniazid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-01
    Completion
    2014-02
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLatent Tuberculosis Infection; Infection in Solid Organ Transplant Recipients
    InterventionLevofloxacin; Isoniazid
    PhasePhase 3
    Registry statusTerminated

  • EARNEST Rifabutin Pharmacokinetics (PK) Substudy

    NCT01663168 · start 2011-12

    Registered record
    Registry ID
    NCT01663168
    Conditions
    HIV; Tuberculosis
    Interventions
    Rifabutin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-12
    Completion
    2014-01
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV; Tuberculosis
    InterventionRifabutin
    PhasePhase 2
    Registry statusUnknown

  • PNU-100480 In Newly Diagnosed, Drug Sensitive Patients With Pulmonary TB; Early Bactericidal Activity; Whole Blood Assay

    NCT01225640 · start 2011-08

    Registered record
    Registry ID
    NCT01225640
    Conditions
    Tuberculosis
    Interventions
    PNU-100480; PNU-100480; RHZE
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-08
    Completion
    2011-12
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPNU-100480; PNU-100480; RHZE
    PhasePhase 2
    Registry statusCompleted

  • Bioequivalence Study Comparing Rifampicin In A Fixed-Dose Combination (Rifampicin+Isoniazid, Myrin© 2) And The Reference Drug (Rifampicin, Rimactane®)

    NCT01311505 · start 2011-04

    Registered record
    Registry ID
    NCT01311505
    Conditions
    Tuberculosis
    Interventions
    Myrin© 2 (Rifampicin + Isoniazid); Rimactane® (Rifampicin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-04
    Completion
    2011-05
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionMyrin© 2 (Rifampicin + Isoniazid); Rimactane® (Rifampicin)
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety of Qinbudan as an Adjunct Therapy for Retreatment Pulmonary Tuberculosis

    NCT02313610 · start 2011-04

    Registered record
    Registry ID
    NCT02313610
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Qinbudan; Qinbudan Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-04
    Completion
    2013-03
    Enrolment
    253

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionQinbudan; Qinbudan Placebo
    PhasePhase 2
    Registry statusCompleted

  • Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)

    NCT01580007 · start 2010-12

    Registered record
    Registry ID
    NCT01580007
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Active Sodium Phenylbutyrate and active cholecalciferol; Placebo Sodium Phenylbutyrate plus active cholecalciferol; Active Sodium Phenylbutyrate and placebo cholecalciferol; Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-12
    Completion
    2014-12
    Enrolment
    288

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionActive Sodium Phenylbutyrate and active cholecalciferol; Placebo Sodium Phenylbutyrate plus active cholecalciferol; Active Sodium Phenylbutyrate and placebo cholecalciferol; Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
    PhasePhase 2
    Registry statusCompleted

  • Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra

    NCT01259219 · start 2010-11

    Registered record
    Registry ID
    NCT01259219
    Conditions
    Children With Confirmed HIV Infection; Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose; Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment
    Interventions
    Mycobutin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2010-11
    Completion
    2012-06
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChildren With Confirmed HIV Infection; Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose; Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment
    InterventionMycobutin
    PhasePhase 1
    Registry statusUnknown

  • Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients

    NCT01059422 · start 2010-10

    Registered record
    Registry ID
    NCT01059422
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Raltegravir; Abacavir/Lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-10
    Completion
    2013-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionRaltegravir; Abacavir/Lamivudine
    PhasePhase 4
    Registry statusCompleted

  • A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects

    NCT01214993 · start 2010-10

    Registered record
    Registry ID
    NCT01214993
    Conditions
    Infections, Human Immunodeficiency Virus and Tuberculosis
    Interventions
    GSK1349572; Placebo; Iohexol Injection; Para-aminohippurate infusion
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-10
    Completion
    2010-11
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Human Immunodeficiency Virus and Tuberculosis
    InterventionGSK1349572; Placebo; Iohexol Injection; Para-aminohippurate infusion
    PhasePhase 1
    Registry statusCompleted

  • Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)

    NCT01215851 · start 2010-10

    Registered record
    Registry ID
    NCT01215851
    Conditions
    Pulmonary Tuberculosis
    Interventions
    PA-824; Pyrazinamide; TMC207; Rifafour; Moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-10
    Completion
    2011-08
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionPA-824; Pyrazinamide; TMC207; Rifafour +1 more
    PhasePhase 2
    Registry statusCompleted

  • Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity

    NCT01456845 · start 2010-08

    Registered record
    Registry ID
    NCT01456845
    Conditions
    Hepatitis; Tuberculosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-08
    Completion
    2012-06
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis; Tuberculosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Pharmacokinetics and Pharmacodynamics of High Versus Standard Dose Rifampicin in Patients With Pulmonary Tuberculosis

    NCT00760149 · start 2010-07

    Registered record
    Registry ID
    NCT00760149
    Conditions
    Tuberculosis
    Interventions
    Rifampicin in higher doses
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-07
    Completion
    2013-09
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifampicin in higher doses
    PhasePhase 2
    Registry statusCompleted

  • Effect of Weight and/or Obesity on Dapsone Drug Concentrations

    NCT01165840 · start 2010-07

    Registered record
    Registry ID
    NCT01165840
    Conditions
    Obesity; Leprosy; Tuberculosis
    Interventions
    Dapsone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-07
    Completion
    2012-05
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Leprosy; Tuberculosis
    InterventionDapsone
    PhasePhase 4
    Registry statusCompleted