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AMR Drug RepurposingSmart Screeningresearch prototype

Tuberculosis

Supported pathogenM. tuberculosisMycobacterium tuberculosis

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “tuberculosis”, “mycobacterium tuberculosis”, “tb”, “latent tb”.

Show all 80

Laboratory measurements against M. tuberculosis recorded in ChEMBL.

Show all 54

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against M. tuberculosis that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

M. tuberculosis has 870 repurposing candidates in all. 35 are already listed above, with a registered study for this condition or a laboratory record, so the other 835 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for M. tuberculosis, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started244 of 249 have a start date · most in 2023 (19)
199420102026

  • Micronutrient Supplementation in in Paediatric Pulmonary Tuberculosis

    NCT00801606 · start 2008-12

    Registered record
    Registry ID
    NCT00801606
    Conditions
    Tuberculosis
    Interventions
    Zinc; Micronutrient without zinc; Micronutrient with zinc; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-06
    Enrolment
    403

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionZinc; Micronutrient without zinc; Micronutrient with zinc; Placebo
    PhasePhase 3
    Registry statusCompleted

  • A Phase I Study to Evaluate Safety and Immunogenicity of AERAS 404 (C-011-404)

    NCT02109874 · start 2008-12

    Registered record
    Registry ID
    NCT02109874
    Conditions
    Tuberculosis
    Interventions
    AERAS-404 (mcg H4/nmol IC31); Sterile buffer containing 10 mmol/L tris and 169 mmol/L NaCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionAERAS-404 (mcg H4/nmol IC31); Sterile buffer containing 10 mmol/L tris and 169 mmol/L NaCl
    PhasePhase 1
    Registry statusCompleted

  • Safety And Efficacy Of Rifabutin In Patients For Non-HIV Patients

    NCT00810407 · start 2008-11

    Registered record
    Registry ID
    NCT00810407
    Conditions
    Tuberculosis; Non-tuberculous Mycobacterial Diseases (Including MAC Disease)
    Interventions
    rifabutin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-11
    Completion
    2016-07
    Enrolment
    628

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Non-tuberculous Mycobacterial Diseases (Including MAC Disease)
    Interventionrifabutin
    PhaseNot recorded
    Registry statusCompleted

  • A Bioequivalence Study of Two Different Dosages of Isoniazid Tablet Formulations in Human Healthy Volunteers

    NCT02043314 · start 2008-10

    Registered record
    Registry ID
    NCT02043314
    Conditions
    Tuberculosis
    Interventions
    Isoniazida
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-03
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionIsoniazida
    PhasePhase 1
    Registry statusCompleted

  • Nevirapine Drug Levels in HIV Positive Patients Also Receiving Rifampicin for Tuberculosis

    NCT00617643 · start 2008-05

    Registered record
    Registry ID
    NCT00617643
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Nevirapine without dose escalation; Nevirapine initiation with dose escalation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionNevirapine without dose escalation; Nevirapine initiation with dose escalation
    PhasePhase 4
    Registry statusCompleted

  • Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO)

    NCT00495651 · start 2008-03

    Registered record
    Registry ID
    NCT00495651
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Antiretroviral medications; Antiretroviral medications+Isoniazid prophylaxis; Antiretroviral medications; Antiretroviral medications+Isoniazid prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2015-01
    Enrolment
    2,073

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionAntiretroviral medications; Antiretroviral medications+Isoniazid prophylaxis; Antiretroviral medications; Antiretroviral medications+Isoniazid prophylaxis
    PhasePhase 3
    Registry statusCompleted

  • Simultaneous Versus Sequential Antiretroviral Therapy (ARV) Therapy and Mycobacterium Tuberculosis (MTB) Treatment

    NCT00737724 · start 2008-03

    Registered record
    Registry ID
    NCT00737724
    Conditions
    HIV; AIDS; Tuberculosis
    Interventions
    Simultaneous ARV and antiMTB; Deferred RV and antiMTB treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-03
    Completion
    2011-02
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV; AIDS; Tuberculosis
    InterventionSimultaneous ARV and antiMTB; Deferred RV and antiMTB treatment
    PhaseNot applicable
    Registry statusTerminated

  • Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients

    NCT00620438 · start 2008-02

    Registered record
    Registry ID
    NCT00620438
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Lumefantrine-artemether and nevirapine; lumefantrine-artemether and efavirenz; Lumefantrine-artemether and rifampicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-02
    Completion
    2011-07
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionLumefantrine-artemether and nevirapine; lumefantrine-artemether and efavirenz; Lumefantrine-artemether and rifampicin
    PhasePhase 4
    Registry statusUnknown

  • Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)

    NCT00495326 · start 2007-12

    Registered record
    Registry ID
    NCT00495326
    Conditions
    Tuberculosis; Aids; Hiv Infections
    Interventions
    Nevirapine based therapy; Efavirenz based therapy; Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2007-12
    Completion
    2011-04
    Enrolment
    570

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Aids; Hiv Infections
    InterventionNevirapine based therapy; Efavirenz based therapy; Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • PA-824-CL-007: Phase IIa Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis

    NCT00567840 · start 2007-08

    Registered record
    Registry ID
    NCT00567840
    Conditions
    Pulmonary Tuberculosis
    Interventions
    PA-824
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-08
    Completion
    2007-12
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionPA-824
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetic Issues of Moxifloxacin Plus Rifapentine

    NCT00460759 · start 2007-06

    Registered record
    Registry ID
    NCT00460759
    Conditions
    Mycobacterium Tuberculosis
    Interventions
    Moxifloxacin; Rifapentine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2007-06
    Completion
    2008-08-24
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycobacterium Tuberculosis
    InterventionMoxifloxacin; Rifapentine
    PhasePhase 1
    Registry statusTerminated

  • Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects

    NCT01828827 · start 2007-03

    Registered record
    Registry ID
    NCT01828827
    Conditions
    Tuberculosis
    Interventions
    PA-824 1000 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-03
    Completion
    2007-03
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPA-824 1000 mg
    PhasePhase 1
    Registry statusCompleted

  • Immediate Versus Deferred Start of Anti-HIV Therapy in HIV-Infected Adults Being Treated for Tuberculosis

    NCT00108862 · start 2006-08

    Registered record
    Registry ID
    NCT00108862
    Conditions
    HIV Infection; Tuberculosis
    Interventions
    Strategy: Immediate ART; Strategy: Deferred ART
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-08
    Completion
    2010-07
    Enrolment
    809

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection; Tuberculosis
    InterventionStrategy: Immediate ART; Strategy: Deferred ART
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Two Once Daily Anti Retroviral Treatment Regimens Along With Anti-tuberculosis Treatment

    NCT00332306 · start 2006-06

    Registered record
    Registry ID
    NCT00332306
    Conditions
    Tuberculosis; Human Immunodeficiency Virus Infections
    Interventions
    Didanosine, Lamivudine, Efavirenz; Didanosine, Lamivudine, Nevirapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2006-06
    Completion
    2011-12
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Human Immunodeficiency Virus Infections
    InterventionDidanosine, Lamivudine, Efavirenz; Didanosine, Lamivudine, Nevirapine
    PhasePhase 3
    Registry statusUnknown

  • A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects.

    NCT03202693 · start 2006-03

    Registered record
    Registry ID
    NCT03202693
    Conditions
    Tuberculosis
    Interventions
    PA-824
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2006-05
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPA-824
    PhasePhase 1
    Registry statusCompleted