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AMR Drug RepurposingSmart Screeningresearch prototype

Tuberculosis

Supported pathogenM. tuberculosisMycobacterium tuberculosis

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “tuberculosis”, “mycobacterium tuberculosis”, “tb”, “latent tb”.

Show all 80

Laboratory measurements against M. tuberculosis recorded in ChEMBL.

Show all 54

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against M. tuberculosis that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

M. tuberculosis has 870 repurposing candidates in all. 35 are already listed above, with a registered study for this condition or a laboratory record, so the other 835 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for M. tuberculosis, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started244 of 249 have a start date · most in 2023 (19)
199420102026

  • TBTC Study 26 PK: Rifapentine Pharmacokinetics in Children During Treatment of Latent TB Infection

    NCT00164450 · start 2005-09

    Registered record
    Registry ID
    NCT00164450
    Conditions
    Tuberculosis
    Interventions
    Isoniazid; Rifapentine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-09
    Completion
    2008-08
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionIsoniazid; Rifapentine
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)

    NCT00298870 · start 2005-06

    Registered record
    Registry ID
    NCT00298870
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Isoniazid; isoniazed
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06
    Completion
    Not recorded
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionIsoniazid; isoniazed
    PhasePhase 4
    Registry statusCompleted

  • A Controlled Trial of a 4-Month Quinolone-Containing Regimen for the Treatment of Pulmonary Tuberculosis

    NCT00216385 · start 2005-01

    Registered record
    Registry ID
    NCT00216385
    Conditions
    Tuberculosis
    Interventions
    Gatifloxacin combined regimen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2005-01
    Completion
    2008-12
    Enrolment
    2,070

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionGatifloxacin combined regimen
    PhasePhase 3
    Registry statusUnknown

  • Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in Botswana

    NCT00164281 · start 2004-11

    Registered record
    Registry ID
    NCT00164281
    Conditions
    Tuberculosis; HIV Infections
    Interventions
    Isoniazid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-11
    Completion
    2011-05
    Enrolment
    1,995

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; HIV Infections
    InterventionIsoniazid
    PhasePhase 4
    Registry statusCompleted

  • Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis

    NCT00396084 · start 2004-02-10

    Registered record
    Registry ID
    NCT00396084
    Conditions
    Tuberculosis
    Interventions
    Gatifloxacin; Isoniazid; Levofloxacin; Linezolid; Moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2004-02-10
    Completion
    2007-12-28
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionGatifloxacin; Isoniazid; Levofloxacin; Linezolid +1 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV

    NCT00080119 · start 2004-02

    Registered record
    Registry ID
    NCT00080119
    Conditions
    HIV Infection; Tuberculosis; Pneumocystis Jiroveci Pneumonia
    Interventions
    Isoniazid (INH); Trimethoprim/Sulfamethoxazole (TMP/SMX); Isoniazid Placebo (PL)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2004-02
    Completion
    2009-05
    Enrolment
    1,354

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection; Tuberculosis; Pneumocystis Jiroveci Pneumonia
    InterventionIsoniazid (INH); Trimethoprim/Sulfamethoxazole (TMP/SMX); Isoniazid Placebo (PL)
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • High-Dose Isoniazid Adjuvant Therapy for Multidrug Resistant Tuberculosis

    NCT00513396 · start 2004-01

    Registered record
    Registry ID
    NCT00513396
    Conditions
    Tuberculosis, Multidrug-Resistant
    Interventions
    Isoniazid; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2004-01
    Completion
    2006-12
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis, Multidrug-Resistant
    InterventionIsoniazid; Placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Effects of Vitamin D Supplementation on Antimycobacterial Immunity

    NCT00157066 · start 2002-12

    Registered record
    Registry ID
    NCT00157066
    Conditions
    Tuberculosis
    Interventions
    Ergocalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2002-12
    Completion
    2006-09
    Enrolment
    230

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionErgocalciferol
    PhaseNot applicable
    Registry statusCompleted

  • Tuberculosis Treatment Shortening Trial

    NCT00130247 · start 2002-04-08

    Registered record
    Registry ID
    NCT00130247
    Conditions
    Tuberculosis
    Interventions
    Ethambutol; Isoniazid; Pyrazinamide; Rifampin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-04-08
    Completion
    2008-11-28
    Enrolment
    394

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionEthambutol; Isoniazid; Pyrazinamide; Rifampin
    PhasePhase 3
    Registry statusCompleted

  • Three Months of Weekly Rifapentine and Isoniazid for M. Tuberculosis Infection

    NCT00023452 · start 2001-06

    Registered record
    Registry ID
    NCT00023452
    Conditions
    Tuberculosis
    Interventions
    RPT + INH once weekly for 3 months given by DOT; Isoniazid (INH) daily for 9 months
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-06
    Completion
    2013-09
    Enrolment
    8,053

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRPT + INH once weekly for 3 months given by DOT; Isoniazid (INH) daily for 9 months
    PhasePhase 3
    Registry statusCompleted

  • Preventive Therapy for Tuberculosis in HIV Infected Persons

    NCT00351702 · start 2001-02

    Registered record
    Registry ID
    NCT00351702
    Conditions
    Human Immunodeficiency Virus; Tuberculosis
    Interventions
    Isoniazid with Ethambutol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-02
    Completion
    2011-06
    Enrolment
    683

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHuman Immunodeficiency Virus; Tuberculosis
    InterventionIsoniazid with Ethambutol
    PhasePhase 3
    Registry statusCompleted

  • Short Course Intermittent Regimens for the Treatment of HIV-Associated Tuberculosis

    NCT00376012 · start 2001-02

    Registered record
    Registry ID
    NCT00376012
    Conditions
    Tuberculosis; Human Immunodeficiency Virus Infections
    Interventions
    Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide); Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2001-02
    Completion
    2008-09
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Human Immunodeficiency Virus Infections
    InterventionAnti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide); Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide)
    PhasePhase 3
    Registry statusUnknown

  • TB Nutrition, Immunology and Epidemiology

    NCT00170404 · start 2000-06

    Registered record
    Registry ID
    NCT00170404
    Conditions
    Mycobacterium Tuberculosis
    Interventions
    Folic Acid; Micronutrients: Vitamins B1, B2, B6, Niacin, B12, C, E.; Selenium; Vitamin A
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2000-06
    Completion
    2005-10
    Enrolment
    887

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycobacterium Tuberculosis
    InterventionFolic Acid; Micronutrients: Vitamins B1, B2, B6, Niacin, B12, C, E.; Selenium; Vitamin A
    PhasePhase 3
    Registry statusCompleted

  • TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine

    NCT00023387 · start 2000-03

    Registered record
    Registry ID
    NCT00023387
    Conditions
    Tuberculosis
    Interventions
    Rifapentine; 25-desacetyl Rifapentine; Isoniazid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2000-03
    Completion
    2001-05
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifapentine; 25-desacetyl Rifapentine; Isoniazid
    PhaseNot applicable
    Registry statusCompleted

  • TBTC Study 23B:Intensive PK of the Nelfinavir Rifabutin Interaction in Patients With HIV-TB

    NCT00023400 · start 2000-02

    Registered record
    Registry ID
    NCT00023400
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Nelfinavir; Rifabutin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2000-02
    Completion
    2002-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionNelfinavir; Rifabutin
    PhasePhase 4
    Registry statusCompleted