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AMR Drug RepurposingSmart Screeningresearch prototype

Tuberculosis

Supported pathogenM. tuberculosisMycobacterium tuberculosis

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “tuberculosis”, “mycobacterium tuberculosis”, “tb”, “latent tb”.

Show all 80

Laboratory measurements against M. tuberculosis recorded in ChEMBL.

Show all 54

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against M. tuberculosis that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

M. tuberculosis has 870 repurposing candidates in all. 35 are already listed above, with a registered study for this condition or a laboratory record, so the other 835 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for M. tuberculosis, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started244 of 249 have a start date · most in 2023 (19)
199420102026

  • Clinical Trial to Investigate the Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI® Following One Month of Isoniazid Treatment in Subjects With Latent Tuberculosis Infection

    NCT01136161 · start 2010-06

    Registered record
    Registry ID
    NCT01136161
    Conditions
    Latent Tuberculosis Infection; Tuberculosis
    Interventions
    RUTI; RUTI; RUTI; RUTI Matching Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-06
    Completion
    2011-05
    Enrolment
    95

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLatent Tuberculosis Infection; Tuberculosis
    InterventionRUTI; RUTI; RUTI; RUTI Matching Placebo
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers

    NCT01162486 · start 2010-04

    Registered record
    Registry ID
    NCT01162486
    Conditions
    Tuberculosis; Tuberculosis, Pulmonary
    Interventions
    Rifampin & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine and midazolam; rifapentine and midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-03
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Tuberculosis, Pulmonary
    InterventionRifampin & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine & midazolam +2 more
    PhasePhase 1
    Registry statusCompleted

  • PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)

    NCT02216331 · start 2010-03

    Registered record
    Registry ID
    NCT02216331
    Conditions
    Tuberculosis
    Interventions
    TMC207; rifapentine; rifampicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-03
    Completion
    2010-05
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionTMC207; rifapentine; rifampicin
    PhasePhase 1
    Registry statusCompleted

  • Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam

    NCT01768273 · start 2009-12

    Registered record
    Registry ID
    NCT01768273
    Conditions
    Tuberculosis
    Interventions
    Midazolam; PA-824
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-12
    Completion
    2010-04
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionMidazolam; PA-824
    PhasePhase 1
    Registry statusCompleted

  • Rifapentine Plus Moxifloxacin for Treatment of Pulmonary Tuberculosis

    NCT00728507 · start 2009-11

    Registered record
    Registry ID
    NCT00728507
    Conditions
    Tuberculosis
    Interventions
    Rifapentine, Moxifloxacin, Pyrazinamide, Isoniazid; Isoniazid, Rifampin, Pyrazinamide, Ethambutol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-11
    Completion
    2013-04
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifapentine, Moxifloxacin, Pyrazinamide, Isoniazid; Isoniazid, Rifampin, Pyrazinamide, Ethambutol
    PhasePhase 2
    Registry statusTerminated

  • Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects (CL-009)

    NCT01830439 · start 2009-09

    Registered record
    Registry ID
    NCT01830439
    Conditions
    Tuberculosis
    Interventions
    PA-824 200mg; PA-824 50mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-01
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionPA-824 200mg; PA-824 50mg
    PhasePhase 1
    Registry statusCompleted

  • Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings

    NCT00091936 · start 2009-08

    Registered record
    Registry ID
    NCT00091936
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    Didanosine; Efavirenz; Lamivudine; Standard TB treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    Not recorded
    Enrolment
    592

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    InterventionDidanosine; Efavirenz; Lamivudine; Standard TB treatment
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (CL-010)

    NCT00944021 · start 2009-08

    Registered record
    Registry ID
    NCT00944021
    Conditions
    Pulmonary Tuberculosis
    Interventions
    PA-824; PA-824; PA-824; Rifafour e-275 mg; PA-824
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-08
    Completion
    2010-05
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionPA-824; PA-824; PA-824; Rifafour e-275 mg +1 more
    PhasePhase 2
    Registry statusCompleted

  • Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis

    NCT01011543 · start 2009-08

    Registered record
    Registry ID
    NCT01011543
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Diagnostic techniques in pulmonary tuberculosis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    2015-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionDiagnostic techniques in pulmonary tuberculosis
    PhaseNot applicable
    Registry statusCompleted

  • Safety And Efficacy Of Rifabutin In HIV Patients

    NCT00810446 · start 2009-06

    Registered record
    Registry ID
    NCT00810446
    Conditions
    Non-tuberculous Mycobacterial Diseases; Tuberculosis; Inhibition of Disseminated Mycobacterium Avium Complex Disease Associated With HIV Infections
    Interventions
    rifabutin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-06
    Completion
    2018-03
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-tuberculous Mycobacterial Diseases; Tuberculosis; Inhibition of Disseminated Mycobacterium Avium Complex Disease Associated With HIV Infections
    Interventionrifabutin
    PhaseNot recorded
    Registry statusCompleted

  • TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB

    NCT00664313 · start 2009-04

    Registered record
    Registry ID
    NCT00664313
    Conditions
    Multi-drug Resistant Tuberculosis; Extensively Drug Resistant Tuberculosis
    Interventions
    Linezolid; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2009-04
    Completion
    2010-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMulti-drug Resistant Tuberculosis; Extensively Drug Resistant Tuberculosis
    InterventionLinezolid; Placebo
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Directly Observed Therapy Short Course-Plus Versus DOTS for Retreatment of Relapsed Pulmonary Tuberculosis in Guangzhou

    NCT01618422 · start 2009-03

    Registered record
    Registry ID
    NCT01618422
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Directly Observed Therapy (DOTS) plus; Directly Observed Therapy (DOTS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-03
    Completion
    2014-02
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionDirectly Observed Therapy (DOTS) plus; Directly Observed Therapy (DOTS)
    PhaseNot applicable
    Registry statusCompleted

  • Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in South Africa

    NCT00640887 · start 2009-02

    Registered record
    Registry ID
    NCT00640887
    Conditions
    HIV Infections; Tuberculosis
    Interventions
    rifabutin in combination with efavirenz; rifabutin in combination with nevirapine; rifabutin in combination with lopinavir/ritonavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-02
    Completion
    2010-10
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Tuberculosis
    Interventionrifabutin in combination with efavirenz; rifabutin in combination with nevirapine; rifabutin in combination with lopinavir/ritonavir
    PhasePhase 2
    Registry statusCompleted

  • Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis

    NCT00816426 · start 2008-12-29

    Registered record
    Registry ID
    NCT00816426
    Conditions
    Tuberculosis
    Interventions
    Rifampicin; Isoniazid; Pyrazinamide; Kanamycin; Moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12-29
    Completion
    2017-12-29
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifampicin; Isoniazid; Pyrazinamide; Kanamycin +1 more
    PhasePhase 1
    Registry statusCompleted

  • TBTC Study 29: Rifapentine During Intensive Phase Tuberculosis (TB) Treatment

    NCT00694629 · start 2008-12

    Registered record
    Registry ID
    NCT00694629
    Conditions
    Pulmonary Tuberculosis
    Interventions
    rifapentine; rifapentine 10 mg/kg; rifapentine 15 mg/kg; rifapentine 20 mg/kg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-12
    Completion
    2013-12
    Enrolment
    334

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    Interventionrifapentine; rifapentine 10 mg/kg; rifapentine 15 mg/kg; rifapentine 20 mg/kg
    PhasePhase 2
    Registry statusCompleted