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AMR Drug RepurposingSmart Screeningresearch prototype

MRSA

Supported pathogenMRSAMethicillin-resistant Staphylococcus aureus

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “mrsa”, “methicillin-resistant”, “methicillin resistant”, “staphylococcus aureus”, “staph aureus”.

Show all 46

Laboratory measurements against MRSA recorded in ChEMBL.

Show all 74

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against MRSA that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

MRSA has 671 repurposing candidates in all. 7 are already listed above, with a registered study for this condition or a laboratory record, so the other 664 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for MRSA, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started73 of 73 have a start date · most in 2010 (8)
199920132026

  • Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

    NCT04297592 · start 2020-06-11

    Registered record
    Registry ID
    NCT04297592
    Conditions
    Infections Joint Prosthetic; Overweight or Obesity; MSSA Colonization; MRSA; Chronic Kidney Diseases; Diabetes; Autoimmune Diseases; Inflammatory Disease; Tobacco Use
    Interventions
    Cephalexin; Doxycycline; Cefadroxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Enrolling by invitation
    Start
    2020-06-11
    Completion
    2028-01
    Enrolment
    4,618

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections Joint Prosthetic; Overweight or Obesity; MSSA Colonization; MRSA +5 more
    InterventionCephalexin; Doxycycline; Cefadroxil
    PhasePhase 4
    Registry statusEnrolling by invitation

  • Penicillin Against Flucloxacillin Treatment Evaluation

    NCT03632642 · start 2019-07-01

    Registered record
    Registry ID
    NCT03632642
    Conditions
    Staphylococcus Aureus
    Interventions
    Benzylpenicillin; Flucloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2019-07-01
    Completion
    2020-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionBenzylpenicillin; Flucloxacillin
    PhasePhase 4
    Registry statusWithdrawn

  • Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia

    NCT03138733 · start 2018-08-26

    Registered record
    Registry ID
    NCT03138733
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Ceftobiprole medocaril; Daptomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-08-26
    Completion
    2022-03-11
    Enrolment
    390

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionCeftobiprole medocaril; Daptomycin
    PhasePhase 3
    Registry statusCompleted

  • S. Aureus Decolonization in HPN Patients.

    NCT03173053 · start 2018-02-08

    Registered record
    Registry ID
    NCT03173053
    Conditions
    Staphylococcus Aureus; Motility Disorder
    Interventions
    Doxycycline; Trimethoprim; Sulfamethoxazole/trimethoprim; Clindamycin; Clarithromycin; Ciprofloxacin; Fusidic Acid; Rifampin; Chlorhexidine; Mupirocin; Betadine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2018-02-08
    Completion
    2021-10-14
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; Motility Disorder
    InterventionDoxycycline; Trimethoprim; Sulfamethoxazole/trimethoprim; Clindamycin +7 more
    PhaseNot applicable
    Registry statusTerminated

  • Retapamulin as a Decolonizing Agent for MRSA

    NCT03304873 · start 2017-12-01

    Registered record
    Registry ID
    NCT03304873
    Conditions
    MRSA
    Interventions
    Retapamulin; Placebo Ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-12-01
    Completion
    2019-03-18
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA
    InterventionRetapamulin; Placebo Ointment
    PhasePhase 3
    Registry statusCompleted

  • Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin

    NCT03246360 · start 2017-11-23

    Registered record
    Registry ID
    NCT03246360
    Conditions
    Infection; Methicillin Susceptible Staphylococcus Aureus Infection; Cloxacillin Treatment
    Interventions
    Modification for administration mode of cloxacillin antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-11-23
    Completion
    2018-09-18
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Methicillin Susceptible Staphylococcus Aureus Infection; Cloxacillin Treatment
    InterventionModification for administration mode of cloxacillin antibiotic
    PhaseNot applicable
    Registry statusCompleted

  • Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making

    NCT03220386 · start 2017-05-01

    Registered record
    Registry ID
    NCT03220386
    Conditions
    Staphylococcus Aureus
    Interventions
    Decolonization by nasal Octinidin treatment and skin washings
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-05-01
    Completion
    2018-08-01
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionDecolonization by nasal Octinidin treatment and skin washings
    PhaseNot applicable
    Registry statusUnknown

  • Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

    NCT02814916 · start 2017-03-30

    Registered record
    Registry ID
    NCT02814916
    Conditions
    Methicillin-Resistant Staphylococcus Aureus; Bacterial Infections; Staphylococcal Skin Infections
    Interventions
    Dalbavancin; Vancomycin; Oxacillin; Flucloxacillin; Cefadroxil; Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-03-30
    Completion
    2024-01-01
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus; Bacterial Infections; Staphylococcal Skin Infections
    InterventionDalbavancin; Vancomycin; Oxacillin; Flucloxacillin +2 more
    PhasePhase 3
    Registry statusCompleted

  • Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence

    NCT02566928 · start 2015-10

    Registered record
    Registry ID
    NCT02566928
    Conditions
    Methicillin-Resistant Staphylococcus Aureus; Recurrence; Staphylococcal Skin Infections; Antibiotic Resistance
    Interventions
    2% mupirocin ointment; Chlorhexidine wash; Hygiene protocol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-10
    Completion
    2018-12-31
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus; Recurrence; Staphylococcal Skin Infections; Antibiotic Resistance
    Intervention2% mupirocin ointment; Chlorhexidine wash; Hygiene protocol
    PhasePhase 4
    Registry statusUnknown

  • Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection

    NCT02365493 · start 2015-08-26

    Registered record
    Registry ID
    NCT02365493
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Beta-Lactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-08-26
    Completion
    2018-10-24
    Enrolment
    358

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionBeta-Lactam
    PhasePhase 3
    Registry statusTerminated

  • Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy

    NCT02363166 · start 2015-08

    Registered record
    Registry ID
    NCT02363166
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Acute Abscess Group
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-08
    Completion
    2018-04-04
    Enrolment
    575

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionAcute Abscess Group
    PhaseNot recorded
    Registry statusCompleted

  • Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children

    NCT02335905 · start 2015-06-03

    Registered record
    Registry ID
    NCT02335905
    Conditions
    Hematogenously Acquired Staphylococcus Aureus Osteomyelitis; Bone Infection; Osteomyelitis
    Interventions
    Ceftaroline Fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2015-06-03
    Completion
    2020-06-16
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHematogenously Acquired Staphylococcus Aureus Osteomyelitis; Bone Infection; Osteomyelitis
    InterventionCeftaroline Fosamil
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Treating Parents to Reduce NICU Transmission of Staphylococcus Aureus Trial

    NCT02223520 · start 2014-11

    Registered record
    Registry ID
    NCT02223520
    Conditions
    Staph Aureus Colonization; Staph Aureus Infection
    Interventions
    Mupirocin and Chlorhexidine; Placebo ointment and placebo cloths
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-11
    Completion
    2019-10-31
    Enrolment
    307

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaph Aureus Colonization; Staph Aureus Infection
    InterventionMupirocin and Chlorhexidine; Placebo ointment and placebo cloths
    PhaseNot applicable
    Registry statusCompleted

  • S. Aureus Screening and Decolonization

    NCT02182115 · start 2014-07

    Registered record
    Registry ID
    NCT02182115
    Conditions
    Wound Infection Due to Staphylococcus Aureus; MRSA Infection of Postoperative Wound
    Interventions
    antiseptic bundle; standard of care
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-07
    Completion
    2016-08
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection Due to Staphylococcus Aureus; MRSA Infection of Postoperative Wound
    Interventionantiseptic bundle; standard of care
    PhasePhase 4
    Registry statusCompleted

  • Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project

    NCT02945241 · start 2014-04

    Registered record
    Registry ID
    NCT02945241
    Conditions
    Methicillin-resistant Staphylococcus Aureus; Sepsis; Critical Illness
    Interventions
    Vancomycin; Cystatin C dosing algorithm; Creatine clearance dosing algorithm
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-04
    Completion
    2016-03
    Enrolment
    399

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus; Sepsis; Critical Illness
    InterventionVancomycin; Cystatin C dosing algorithm; Creatine clearance dosing algorithm
    PhasePhase 1
    Registry statusCompleted