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AMR Drug RepurposingSmart Screeningresearch prototype

MRSA

Supported pathogenMRSAMethicillin-resistant Staphylococcus aureus

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “mrsa”, “methicillin-resistant”, “methicillin resistant”, “staphylococcus aureus”, “staph aureus”.

Show all 46

Laboratory measurements against MRSA recorded in ChEMBL.

Show all 74

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against MRSA that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

MRSA has 671 repurposing candidates in all. 7 are already listed above, with a registered study for this condition or a laboratory record, so the other 664 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for MRSA, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started73 of 73 have a start date · most in 2010 (8)
199920132026

  • Detection, Education, Research and Decolonization Without Isolation in Long-term Care Facilities

    NCT01302210 · start 2010-10

    Registered record
    Registry ID
    NCT01302210
    Conditions
    Methicillin Resistant Staphylococcus Aureus
    Interventions
    Decolonization
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-10
    Completion
    2014-11
    Enrolment
    22,302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus
    InterventionDecolonization
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Intranasal Mupirocin on Rate of Staphylococcus Aureus Surgical Site Infection Following Cesarean Sections

    NCT01152593 · start 2010-07

    Registered record
    Registry ID
    NCT01152593
    Conditions
    Surgical Wound Infection; Cesarean Section; Staphylococcus Aureus
    Interventions
    Mupirocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-07
    Completion
    2014-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection; Cesarean Section; Staphylococcus Aureus
    InterventionMupirocin
    PhaseNot applicable
    Registry statusUnknown

  • Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

    NCT01232231 · start 2010-07

    Registered record
    Registry ID
    NCT01232231
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    pharmacological decolonization treatment; Education
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-07
    Completion
    2012-11
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    Interventionpharmacological decolonization treatment; Education
    PhaseNot applicable
    Registry statusCompleted

  • Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus

    NCT01141101 · start 2010-06

    Registered record
    Registry ID
    NCT01141101
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-06
    Completion
    2012-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees

    NCT01105767 · start 2010-05

    Registered record
    Registry ID
    NCT01105767
    Conditions
    Staphylococcus Aureus; MRSA Skin Infections; Staphylococcal Skin Infections
    Interventions
    Chlorhexidine gluconate; Supplemental training, education and hygiene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-01
    Enrolment
    30,209

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; MRSA Skin Infections; Staphylococcal Skin Infections
    InterventionChlorhexidine gluconate; Supplemental training, education and hygiene
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess

    NCT01498744 · start 2010-02

    Registered record
    Registry ID
    NCT01498744
    Conditions
    Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    Interventions
    Oral Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2013-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    InterventionOral Clindamycin
    PhaseNot applicable
    Registry statusTerminated

  • Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community

    NCT00966446 · start 2009-09

    Registered record
    Registry ID
    NCT00966446
    Conditions
    MRSA - Methicillin Resistant Staphylococcus Aureus Infection
    Interventions
    Unsupervised Decolonization; Supervised Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2014-12
    Enrolment
    223

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA - Methicillin Resistant Staphylococcus Aureus Infection
    InterventionUnsupervised Decolonization; Supervised Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)

    NCT00980980 · start 2009-09

    Registered record
    Registry ID
    NCT00980980
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Chlorhexidine bath and nasal mupirocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-09
    Enrolment
    74,256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionChlorhexidine bath and nasal mupirocin
    PhaseNot applicable
    Registry statusCompleted

  • Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment

    NCT00997139 · start 2009-09

    Registered record
    Registry ID
    NCT00997139
    Conditions
    Nasal Carriers of Staphylococcus Aureus
    Interventions
    Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-11
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasal Carriers of Staphylococcus Aureus
    InterventionNeosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
    PhaseNot applicable
    Registry statusCompleted

  • Treatment of Patients Colonized With Methicillin-Resistant Staphylococcus Aureus Prior to Bone and Joint Surgery

    NCT00903279 · start 2009-08

    Registered record
    Registry ID
    NCT00903279
    Conditions
    Orthopedic Procedures; Methicillin-resistant Staphylococcus Aureus
    Interventions
    Placebo; Altabax (retapamulin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2009-08
    Completion
    2010-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrthopedic Procedures; Methicillin-resistant Staphylococcus Aureus
    InterventionPlacebo; Altabax (retapamulin)
    PhasePhase 2
    Registry statusWithdrawn

  • Rifabutin Based Therapy for the Eradication of Staphylococcus Aureus Colonization in HIV Infected Adults

    NCT00869518 · start 2009-07

    Registered record
    Registry ID
    NCT00869518
    Conditions
    Staphylococcus Aureus; HIV Infections
    Interventions
    rifabutin plus trimethoprim sulfamethoxazole; placebo plus trimethoprim-sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-07
    Completion
    2010-12
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; HIV Infections
    Interventionrifabutin plus trimethoprim sulfamethoxazole; placebo plus trimethoprim-sulfamethoxazole
    PhasePhase 2
    Registry statusTerminated

  • Efficacy Study of Altabax to Clear Methicillin-resistant Staphylococcus Aureus (MRSA) Nasal Colonization

    NCT00856089 · start 2009-05

    Registered record
    Registry ID
    NCT00856089
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Retapamulin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2009-05
    Completion
    2009-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionRetapamulin
    PhasePhase 4
    Registry statusWithdrawn

  • Clinical Trial on the Reduction of Methicillin Resistant Staphylococcus Aureus (MRSA)

    NCT00790608 · start 2009-01

    Registered record
    Registry ID
    NCT00790608
    Conditions
    Skin Ulcers; Methicillin-resistant Staphylococcus Aureus Infection
    Interventions
    Nitric Oxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-01
    Completion
    2011-08
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Ulcers; Methicillin-resistant Staphylococcus Aureus Infection
    InterventionNitric Oxide
    PhasePhase 2
    Registry statusTerminated

  • Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery

    NCT00701636 · start 2008-07

    Registered record
    Registry ID
    NCT00701636
    Conditions
    Late Effects of Surgery; Staphylococcus Aureus; Surgical Site Infection
    Interventions
    daptomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-10
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLate Effects of Surgery; Staphylococcus Aureus; Surgical Site Infection
    Interventiondaptomycin
    PhasePhase 3
    Registry statusCompleted

  • Staphylococcus Aureus Decolonization Study

    NCT00731783 · start 2008-07

    Registered record
    Registry ID
    NCT00731783
    Conditions
    Staphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus; MRSA Infection
    Interventions
    2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-12
    Enrolment
    183

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus +1 more
    Intervention2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    PhaseNot applicable
    Registry statusCompleted