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AMR Drug RepurposingSmart Screeningresearch prototype

MRSA

Supported pathogenMRSAMethicillin-resistant Staphylococcus aureus

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “mrsa”, “methicillin-resistant”, “methicillin resistant”, “staphylococcus aureus”, “staph aureus”.

Show all 46

Laboratory measurements against MRSA recorded in ChEMBL.

Show all 74

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against MRSA that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

MRSA has 671 repurposing candidates in all. 7 are already listed above, with a registered study for this condition or a laboratory record, so the other 664 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for MRSA, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started73 of 73 have a start date · most in 2010 (8)
199920132026

  • Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

    NCT00685867 · start 2008-05

    Registered record
    Registry ID
    NCT00685867
    Conditions
    MRSA Infection
    Interventions
    Rapid molecular MRSA test; Hand hygiene promotion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-12
    Enrolment
    126,750

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA Infection
    InterventionRapid molecular MRSA test; Hand hygiene promotion
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Decolonization of Methicillin-resistant Staphylococcus Aureus (MRSA) Using Theraworx

    NCT00713674 · start 2008-03

    Registered record
    Registry ID
    NCT00713674
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Theraworx; mupirocin antibiotic ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2008-03
    Completion
    2009-02
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionTheraworx; mupirocin antibiotic ointment
    PhaseNot applicable
    Registry statusWithdrawn

  • A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA

    NCT00532324 · start 2008-02

    Registered record
    Registry ID
    NCT00532324
    Conditions
    Staphylococcus Aureus
    Interventions
    CA-MRSA Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionCA-MRSA Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Incidence and Relationship of Positive Preoperative Methicillin Resistant Staphylococcus Aureus (MRSA) Screens and Post-operative Infections

    NCT01028105 · start 2008-02

    Registered record
    Registry ID
    NCT01028105
    Conditions
    Methicillin-resistant Staphylococcus Aureus Infection
    Interventions
    Preoperative MRSA screening
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    975

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus Infection
    InterventionPreoperative MRSA screening
    PhaseNot applicable
    Registry statusTerminated

  • Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis

    NCT00967941 · start 2007-08

    Registered record
    Registry ID
    NCT00967941
    Conditions
    MRSA Infections
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-08
    Completion
    2010-08
    Enrolment
    169

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA Infections
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection

    NCT00560599 · start 2007-04

    Registered record
    Registry ID
    NCT00560599
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    mupirocin and chlorhexidine; household cleaning and disinfection; mupirocin, chlorhexidine, & household cleaning/disinfection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2012-12
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionmupirocin and chlorhexidine; household cleaning and disinfection; mupirocin, chlorhexidine, & household cleaning/disinfection
    PhasePhase 3
    Registry statusCompleted

  • The Natural History of Community-Associated MRSA Infections and Decolonization Strategies

    NCT00513799 · start 2007-03

    Registered record
    Registry ID
    NCT00513799
    Conditions
    Abscesses; Furunculosis; Staphylococcus Aureus; Staphylococcal Skin Infections
    Interventions
    Mupirocin ointment; Chlorhexidine showers; Bleach baths (dilute); Intensive education on personal hygiene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscesses; Furunculosis; Staphylococcus Aureus; Staphylococcal Skin Infections
    InterventionMupirocin ointment; Chlorhexidine showers; Bleach baths (dilute); Intensive education on personal hygiene
    PhaseNot applicable
    Registry statusCompleted

  • A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections

    NCT01049438 · start 2006-08

    Registered record
    Registry ID
    NCT01049438
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    nasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-08
    Completion
    2009-09
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionnasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    PhaseNot applicable
    Registry statusCompleted

  • An Attempt to Reduce Community-Acquired Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection in Soldiers

    NCT00289588 · start 2005-01

    Registered record
    Registry ID
    NCT00289588
    Conditions
    Community-Acquired MRSA Infections; Abscesses; Cellulitis; Folliculitis
    Interventions
    Mupirocin (drug)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-12
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-Acquired MRSA Infections; Abscesses; Cellulitis; Folliculitis
    InterventionMupirocin (drug)
    PhaseNot applicable
    Registry statusCompleted

  • Nosocomial Pneumonia With Suspected Or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

    NCT00084266 · start 2004-10

    Registered record
    Registry ID
    NCT00084266
    Conditions
    Methicillin Resistant Staphylococcus Aureus (MRSA)
    Interventions
    linezolid (Zyvox); vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-10
    Completion
    2010-03
    Enrolment
    1,225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus (MRSA)
    Interventionlinezolid (Zyvox); vancomycin
    PhasePhase 4
    Registry statusCompleted

  • Skin Structure Infections With Suspected or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

    NCT00087490 · start 2004-10

    Registered record
    Registry ID
    NCT00087490
    Conditions
    Skin/Soft Tissue Infections; Methicillin Resistant Staphylococcus Aureus (MRSA)
    Interventions
    linezolid; vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-10
    Completion
    2007-07
    Enrolment
    1,077

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin/Soft Tissue Infections; Methicillin Resistant Staphylococcus Aureus (MRSA)
    Interventionlinezolid; vancomycin
    PhasePhase 4
    Registry statusCompleted

  • Cefazolin Versus Antistaphylococcal Penicillins for Methicillin Susceptible Staphylococcus Aureus Bacteremia

    NCT07186894 · start 2000-01-01

    Registered record
    Registry ID
    NCT07186894
    Conditions
    Bacteriemia; Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection
    Interventions
    Antistaphylococcal penicillins; Cefazolin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2000-01-01
    Completion
    2026-09-01
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteriemia; Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection
    InterventionAntistaphylococcal penicillins; Cefazolin
    PhaseNot recorded
    Registry statusActive not recruiting

  • Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia

    NCT00548002 · start 1999-01

    Registered record
    Registry ID
    NCT00548002
    Conditions
    Staphylococcus Aureus; Bacteremia; Endocarditis; Sepsis
    Interventions
    trovafloxacin and levofloxacin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    1999-01
    Completion
    2002-08
    Enrolment
    430

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; Bacteremia; Endocarditis; Sepsis
    Interventiontrovafloxacin and levofloxacin
    PhaseNot recorded
    Registry statusCompleted