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AMR Drug RepurposingSmart Screeningresearch prototype

MRSA

Supported pathogenMRSAMethicillin-resistant Staphylococcus aureus

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “mrsa”, “methicillin-resistant”, “methicillin resistant”, “staphylococcus aureus”, “staph aureus”.

Show all 46

Laboratory measurements against MRSA recorded in ChEMBL.

Show all 74

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against MRSA that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

MRSA has 671 repurposing candidates in all. 7 are already listed above, with a registered study for this condition or a laboratory record, so the other 664 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for MRSA, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started73 of 73 have a start date · most in 2010 (8)
199920132026

  • Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia

    NCT01975662 · start 2014-01

    Registered record
    Registry ID
    NCT01975662
    Conditions
    Bacteremia Due to Staphylococcus Aureus
    Interventions
    Daptomycin; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-01
    Completion
    2015-12
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia Due to Staphylococcus Aureus
    InterventionDaptomycin; Vancomycin
    PhasePhase 2
    Registry statusTerminated

  • Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin

    NCT02443064 · start 2014-01

    Registered record
    Registry ID
    NCT02443064
    Conditions
    Blood Stream Infections; Endocarditis; MRSA
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-01
    Completion
    2016-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Stream Infections; Endocarditis; MRSA
    InterventionVancomycin
    PhasePhase 4
    Registry statusUnknown

  • Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

    NCT01792804 · start 2013-12

    Registered record
    Registry ID
    NCT01792804
    Conditions
    Staphylococcus Aureus Infection
    Interventions
    Trimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin; Cloxacillin; Vancomycin; Daptomycin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-12
    Completion
    2020-03-26
    Enrolment
    215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Infection
    InterventionTrimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin +4 more
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia

    NCT01898338 · start 2013-12

    Registered record
    Registry ID
    NCT01898338
    Conditions
    Staph Aureus Methicillin Resistant Bacteremia
    Interventions
    Fosfomycin 2gr/6h iv; Daptomycin 10mg/kg/24h iv
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-12
    Completion
    2018-01-10
    Enrolment
    167

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaph Aureus Methicillin Resistant Bacteremia
    InterventionFosfomycin 2gr/6h iv; Daptomycin 10mg/kg/24h iv
    PhasePhase 3
    Registry statusCompleted

  • Impact of Mupirocin Decolonization on the Nasal Microbiome

    NCT02045329 · start 2013-10

    Registered record
    Registry ID
    NCT02045329
    Conditions
    Nasal Colonization With Staph Aureus
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2013-10
    Completion
    2015-06-05
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasal Colonization With Staph Aureus
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia

    NCT01701219 · start 2013-01

    Registered record
    Registry ID
    NCT01701219
    Conditions
    Staphylococcus Aureus Bacteremia; Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia
    Interventions
    Ceftaroline fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-07
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia; Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia
    InterventionCeftaroline fosamil
    PhasePhase 4
    Registry statusCompleted

  • Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia

    NCT01911624 · start 2013-01

    Registered record
    Registry ID
    NCT01911624
    Conditions
    Staphylococcus Aureus Bacteraemia
    Interventions
    direct thrombin inhibition; enoxaparin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-01
    Completion
    2016-07
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteraemia
    Interventiondirect thrombin inhibition; enoxaparin
    PhasePhase 2
    Registry statusCompleted

  • Retapamulin for Reducing MRSA Nasal Carriage

    NCT01461668 · start 2012-07

    Registered record
    Registry ID
    NCT01461668
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Retapamulin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-07
    Completion
    2017-12
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionRetapamulin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

    NCT01431326 · start 2011-11

    Registered record
    Registry ID
    NCT01431326
    Conditions
    Adenovirus; Anesthesia; Anxiety; Anxiolysis; Autism; Autistic Disorder; Bacterial Meningitis; Bacterial Septicemia; Benzodiazepine; Bipolar Disorder; Bone and Joint Infections; Central Nervous System Infections; Convulsions; Cytomegalovirus Retinitis; Early-onset Schizophrenia Spectrum Disorders; Epilepsy; General Anesthesia; Gynecologic Infections; Herpes Simplex Virus; Infantile Hemangioma; Infection; Inflammation; Inflammatory Conditions; Intra-abdominal Infections; Lower Respiratory Tract Infections; Migraines; Pain; Pneumonia; Schizophrenia; Sedation; Seizures; Skeletal Muscle Spasms; Skin and Skin-structure Infections; Treatment-resistant Schizophrenia; Urinary Tract Infections; Withdrawal; Sepsis; Gram-negative Infection; Bradycardia; Cardiac Arrest; Cardiac Arrhythmia; Staphylococcal Infections; Nosocomial Pneumonia; Neuromuscular Blockade; Methicillin Resistant Staphylococcus Aureus; Endocarditis; Neutropenia; Headache; Fibrinolytic Bleeding; Pulmonary Arterial Hypertension; C
    Interventions
    The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11
    Completion
    2019-11
    Enrolment
    3,520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus; Anesthesia; Anxiety; Anxiolysis +47 more
    InterventionThe POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusCompleted

  • Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia

    NCT01356472 · start 2011-06

    Registered record
    Registry ID
    NCT01356472
    Conditions
    Methicillin-resistant Staphylococcus Aureus; Pneumonia, Ventilator-Associated
    Interventions
    Imipenem/cilastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-06
    Completion
    Not recorded
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus; Pneumonia, Ventilator-Associated
    InterventionImipenem/cilastatin
    PhasePhase 4
    Registry statusUnknown

  • Vascular Surgical Antibiotic Prophylaxis Study (VSAPS 2)

    NCT01612052 · start 2011-05

    Registered record
    Registry ID
    NCT01612052
    Conditions
    MRSA - Methicillin Resistant Staphylococcus Aureus Infection
    Interventions
    Antibiotic Prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2013-10
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA - Methicillin Resistant Staphylococcus Aureus Infection
    InterventionAntibiotic Prophylaxis
    PhasePhase 4
    Registry statusUnknown

  • Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

    NCT01349192 · start 2011-04

    Registered record
    Registry ID
    NCT01349192
    Conditions
    Cystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    Interventions
    Rifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin; chlorhexidine gluconate oral rinse; 2% Chlorhexidine solution wipes; Environmental Decontamination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-04
    Completion
    2015-05
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    InterventionRifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin +3 more
    PhasePhase 2
    Registry statusTerminated

  • Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes

    NCT01148485 · start 2011-01

    Registered record
    Registry ID
    NCT01148485
    Conditions
    Staphylococcus Aureus
    Interventions
    Nasal, throat, inguinal and skin lesions swab samples will be performed
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionNasal, throat, inguinal and skin lesions swab samples will be performed
    PhaseNot recorded
    Registry statusCompleted

  • Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

    NCT01196169 · start 2010-10

    Registered record
    Registry ID
    NCT01196169
    Conditions
    Staphylococcal Infections; Methicillin-resistant Staphylococcus Aureus
    Interventions
    Daptomycin; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2010-10
    Completion
    2014-03
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Infections; Methicillin-resistant Staphylococcus Aureus
    InterventionDaptomycin; Vancomycin
    PhasePhase 4
    Registry statusTerminated

  • Initial Treatment for Acute Bacterial Skin Infections (ABSSSI) Caused by Staphylococcus Aureus

    NCT01211470 · start 2010-10

    Registered record
    Registry ID
    NCT01211470
    Conditions
    Acute Bacterial Skin and Skin-structure Infection(ABSSSI) Due to Staphylococcus Aureus (MSSA); (Susceptible or Methicillin Resistant)
    Interventions
    Daptomycin; PMX-30063-investigational drug
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-10
    Completion
    2012-03
    Enrolment
    215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Bacterial Skin and Skin-structure Infection(ABSSSI) Due to Staphylococcus Aureus (MSSA); (Susceptible or Methicillin Resistant)
    InterventionDaptomycin; PMX-30063-investigational drug
    PhasePhase 2
    Registry statusCompleted