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AMR Drug RepurposingSmart Screeningresearch prototype

MRSA infection

Supported pathogenMRSAMethicillin-resistant Staphylococcus aureus

Medicines already documented

Documented evidence

Registered studies whose listed conditions mention “mrsa”, “methicillin-resistant”, “methicillin resistant”, “staphylococcus aureus”, “staph aureus”, “mrsa infection”.

Show all 46

Laboratory measurements against MRSA recorded in ChEMBL.

Show all 74

Other medicines to investigate

AI prediction · nothing measured

Approved medicines with AI-predicted activity ≥40% against MRSA that are not already antimicrobials, have no registered study for this condition and have no laboratory record against it. Each shows what it is already used for. They were surfaced computationally for further investigation and are not presented as established treatments for this condition.

MRSA has 671 repurposing candidates in all. 7 are already listed above, with a registered study for this condition or a laboratory record, so the other 664 are listed here.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Every repurposing candidate for MRSA, including those with documented evidence →

Registered studies

A registration describes a study; it does not establish a positive result.

When these studies started73 of 73 have a start date · most in 2010 (8)
199920132026

  • Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia

    NCT07376889 · start 2026-02-01

    Registered record
    Registry ID
    NCT07376889
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Antibiotic Monotherapy (AM) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB); Antibiotic Monotherapy (AM) for patients with methicillin-resistant S. aureus bacteremia (MRSAB); Combination Antibiotic Therapy (CAT) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB); Combination Antibiotic Therapy (CAT) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-02-01
    Completion
    2029-01
    Enrolment
    2,096

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionAntibiotic Monotherapy (AM) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB); Antibiotic Monotherapy (AM) for patients with methicillin-resistant S. aureus bacteremia (MRSAB); Combination Antibiotic Therapy (CAT) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB); Combination Antibiotic Therapy (CAT) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)
    PhasePhase 4
    Registry statusRecruiting

  • Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes?

    NCT07148960 · start 2025-09-15

    Registered record
    Registry ID
    NCT07148960
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Early Dual IV Antibiotic Therapy - MRSA; Early Dual IV Antibiotic Therapy - MSSA; Single Agent IV Antibiotic Therapy - MRSA; Single Agent IV Antibiotic Therapy - MSSA
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Enrolling by invitation
    Start
    2025-09-15
    Completion
    2027-07
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionEarly Dual IV Antibiotic Therapy - MRSA; Early Dual IV Antibiotic Therapy - MSSA; Single Agent IV Antibiotic Therapy - MRSA; Single Agent IV Antibiotic Therapy - MSSA
    PhasePhase 4
    Registry statusEnrolling by invitation

  • Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

    NCT06982105 · start 2025-05-20

    Registered record
    Registry ID
    NCT06982105
    Conditions
    Methicillin Resistant Staphylococcus Aureus; Osteomyelitis Acute; Septic Arthritis; Orbital Cellulitis; Facial Cellulitis; Mastoiditis; Cervical Adenitis; Retropharyngeal Abscess; Peritonsillar Abscess
    Interventions
    Trimethoprim Sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-05-20
    Completion
    2027-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus; Osteomyelitis Acute; Septic Arthritis; Orbital Cellulitis +5 more
    InterventionTrimethoprim Sulfamethoxazole
    PhasePhase 4
    Registry statusRecruiting

  • Decolonization Efficacy of Polyhexanide vs. Mupirocin

    NCT06633588 · start 2025-05-01

    Registered record
    Registry ID
    NCT06633588
    Conditions
    Staphylococcus Aureus; Colonization, Asymptomatic
    Interventions
    Polyhexanide; Mupirocin and Chlorhexidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-05-01
    Completion
    2026-06-30
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; Colonization, Asymptomatic
    InterventionPolyhexanide; Mupirocin and Chlorhexidine
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

    NCT06726395 · start 2025-03-10

    Registered record
    Registry ID
    NCT06726395
    Conditions
    Staphylococcus Aureus Bacteraemia; Staphylococcal Bacteraemia; Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia); Staphylococcus (S.) Aureus Infection
    Interventions
    Penicillin G_1200mg; cloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-03-10
    Completion
    2028-07
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteraemia; Staphylococcal Bacteraemia; Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia) +1 more
    InterventionPenicillin G_1200mg; cloxacillin
    PhasePhase 4
    Registry statusRecruiting

  • Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection

    NCT06456424 · start 2024-11-20

    Registered record
    Registry ID
    NCT06456424
    Conditions
    Prosthetic Joint Infections of Hip; Staphylococcus Aureus Infection
    Interventions
    Phage therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Active not recruiting
    Start
    2024-11-20
    Completion
    2025-11
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProsthetic Joint Infections of Hip; Staphylococcus Aureus Infection
    InterventionPhage therapy
    PhasePhase 1 / Phase 2
    Registry statusActive not recruiting

  • Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia

    NCT06695832 · start 2024-11-01

    Registered record
    Registry ID
    NCT06695832
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2024-11-01
    Completion
    2025-01-31
    Enrolment
    369

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusActive not recruiting

  • PMT for MDRO Decolonization

    NCT05632315 · start 2024-08-19

    Registered record
    Registry ID
    NCT05632315
    Conditions
    Multidrug Resistant Bacterial Infection; Enterobacteriaceae Infections; Pseudomonas Aeruginosa; VRE Infection; Methicillin-resistant Staphylococcus Aureus
    Interventions
    PMT
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2024-08-19
    Completion
    2026-08
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultidrug Resistant Bacterial Infection; Enterobacteriaceae Infections; Pseudomonas Aeruginosa; VRE Infection +1 more
    InterventionPMT
    PhasePhase 2
    Registry statusActive not recruiting

  • Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia

    NCT06336824 · start 2024-06-28

    Registered record
    Registry ID
    NCT06336824
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid; IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2024-06-28
    Completion
    2025-06
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionTab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid; IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline
    PhasePhase 3
    Registry statusUnknown

  • Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia

    NCT04886284 · start 2024-05-20

    Registered record
    Registry ID
    NCT04886284
    Conditions
    Staphylococcus Aureus Bacteremia; Staphylococcus Aureus Septicemia; Staphylococcal Sepsis; Staphylococcus Aureus Endocarditis
    Interventions
    Ertapenem; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2024-05-20
    Completion
    2027-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia; Staphylococcus Aureus Septicemia; Staphylococcal Sepsis; Staphylococcus Aureus Endocarditis
    InterventionErtapenem; Placebo
    PhasePhase 2
    Registry statusRecruiting

  • Adjunctive Clindamycin for the Treatment of Skin and Soft Tissue Infections, a Randomized Controlled Trial

    NCT05899140 · start 2024-03-15

    Registered record
    Registry ID
    NCT05899140
    Conditions
    Skin Infection; Staphylococcal Infections; Staphylococcus Aureus Infection
    Interventions
    Clindamycin; Standard of care
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-03-15
    Completion
    2026-07-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Infection; Staphylococcal Infections; Staphylococcus Aureus Infection
    InterventionClindamycin; Standard of care
    PhasePhase 4
    Registry statusRecruiting

  • Plasma Pharmacological Monitoring of M Penicillins in Methicillin-sensitive Staphylococcus Aureus Bacteremia

    NCT06495697 · start 2023-07-19

    Registered record
    Registry ID
    NCT06495697
    Conditions
    Staphylococcus Aureus Infection
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-07-19
    Completion
    2024-07-19
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Infection
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC

    NCT04793152 · start 2023-03-20

    Registered record
    Registry ID
    NCT04793152
    Conditions
    MRSA
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-03-20
    Completion
    2029-10
    Enrolment
    700

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA
    InterventionVancomycin
    PhaseNot applicable
    Registry statusRecruiting

  • Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Sohag University Hospitals

    NCT06291181 · start 2023-01-01

    Registered record
    Registry ID
    NCT06291181
    Conditions
    Staphylococcus Aureus
    Interventions
    antibiotic sensitivity test
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-01-01
    Completion
    2023-06-30
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    Interventionantibiotic sensitivity test
    PhaseNot applicable
    Registry statusCompleted

  • Staphylococcus Aureus Network Adaptive Platform Trial

    NCT05137119 · start 2022-02-16

    Registered record
    Registry ID
    NCT05137119
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Cefazolin; Penicillin; Clindamycin; Vancomycin; Effectiveness of early switch to oral antibiotics; Whole body FDG PET/CT Imaging
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-02-16
    Completion
    2028-12-01
    Enrolment
    8,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionCefazolin; Penicillin; Clindamycin; Vancomycin +2 more
    PhasePhase 4
    Registry statusRecruiting